2X4W,3L42


Conserved Protein Domain Family
PWWP_BRPF1
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cd20156: PWWP_BRPF1 
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PWWP domain found in bromodomain and PHD finger-containing protein 1 (BRPF1)
BRPF1, also called peregrin, or protein Br140, is a multi-domain protein that binds histones, mediates monocytic leukemic zinc-finger protein (MOZ)-dependent histone acetylation, and is required for Hox gene expression and segmental identity. It is a close partner of the MOZ histone acetyltransferase (HAT) complex and a novel Trithorax group (TrxG) member with a central role during development. BRPF1 is primarily a nuclear protein that has a broad tissue distribution and is abundant in testes and spermatogonia. It may be involved in chromatin remodeling. It contains a plant homeodomain (PHD) zinc finger followed by a non-canonical extended PHD (ePHD) finger, C2HC5HC2H, a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain. The PHD finger binds to methylated lysine 4 of histone H3 (K4H3), the bromodomain interacts with acetylated lysines on N-terminal tails of histones and other proteins, and the PWWP domain shows histone-binding and chromatin association properties.
Links
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Statistics
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PSSM-Id: 438984
Aligned: 8 rows
Threshold Bit Score: 233.368
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyl-histonePWWP sequence
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:methyl-histone binding site [polypeptide binding site]
Evidence:
  • Structure:2X4W; Homo sapiens BRPF1 binds H3K36me3 peptide in an aromatic cage; contacts at 4A
  • Comment:the aromatic residues form the three-walled methyl-lysine cage that directly participate in histone methylated lysine binding and recognition.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #  #                   ###  # #   #               ## # #####       
2X4W_A         10 LDALDLVWAKCRGYPSYPALIIDPKMPREgMFHHGVPIPVPPLEVLKLGEQMTQEarEHLYLVLFFDnKRTWQWLPRtKL 89   human
3L42_A          6 LDALDLVWAKCRGYPSYPALIIDPKMPREgMFHHGVPIPVPPLEVLKLGEQMTQEarEHLYLVLFFDnKRTWQWLPRtKL 85   human
NP_001026635 1087 LDALDLVWAKCRGYPSYPALIIDPKMPREgMFHHGVPIPVPPLEVLKLGEQMTQEarEHLYLVLFFDnKRTWQWLPRtKL 1166 chicken
P55201       1083 LDALDLVWAKCRGYPSYPALIIDPKMPREgMFHHGVPIPVPPLEVLKLGEQMTQEarEHLYLVLFFDnKRTWQWLPRtKL 1162 human
XP_007888451 1070 LEALDLVWAKCRGYPSYPALIIDPKMPREgLYHHGVPIPVPPLDVLKLGEQMTVEarEHLYLVLFFDnKRTWQWLPRtKL 1149 elephant shark
ACC94158     1127 LDALDLVWAKCRGYPSYPALIIDPKMPREgVFHRGVPIPVPPLEVLKLGEQMTQEarEHLFLVLFFDnKRTWQWLPRsKL 1206 zebrafish
XP_006001265 1082 LEALDLVWAKCRGYPSYPALIIDPKMPREgMFHHSVPIPVPPQEVLKLGEQMTQEaqEHLYLVLFFDnKRTWQWLPRtKL 1161 coelacanth
NP_001106468  799 LEALDLVWAKCRGYPSYPALIIDPKMPREgVFHHGVPIPVPPVDVLKLGEQMAQEaqEHLYLVLFFDnKRTWQWLPRtKL 878  tropical claw...

Feature 1                                                 
2X4W_A         90 VPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRSKV 129  human
3L42_A         86 VPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRSKV 125  human
NP_001026635 1167 VPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRAMQHRNKV 1206 chicken
P55201       1163 VPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRSKV 1202 human
XP_007888451 1150 VPLGVDQTMDKMKMLEGRKSNIRKSVQIAYHRAMQHRSKV 1189 elephant shark
ACC94158     1207 VPLGVNQDLDKEKMLEGRKSNIRKSVQVAYHRAMQHRNKV 1246 zebrafish
XP_006001265 1162 VPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRAMQHRNKV 1201 coelacanth
NP_001106468  879 VPLGMNRELDKEKMLEGRKSNIRKSVQIAYDRAMQHRNKV 918  tropical clawed frog

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