Conserved Protein Domain Family
PWWP_ZCWPW2
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cd20146: PWWP_ZCWPW2 
PWWP domain found in zinc finger CW-type PWWP domain protein 2 (ZCWPW2) and similar proteins
ZCWPW2 is a histone H3K4me3 reader. In addition to the PWWP domain, ZCWPW2 contains a zinc finger CW (zf-CW) domain that is a histone modification reader for the histone H3 tail with trimethylated K4. The PWWP domain specifically recognizes DNA and histone methylated lysines.
Links
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Statistics
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PSSM-Id: 438974
Aligned: 22 rows
Threshold Bit Score: 120.863
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Feature 1:putative methyl-histone binding site [polypeptide binding site]
Evidence:
  • Comment:the aromatic residues form the three-walled methyl-lysine cage that directly participate in histone methylated lysine binding and recognition.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             #  #                                        #              
Q504Y3        88 GFKIVYSQLPLGSLVLVKLqnWPSWPGILCPDRf--kGKYVTYDPDGn----------VEEYHIEFLGDPHSRSWIKa-- 153 human
XP_021376337 126 GLNYVMSQLAQGTIVWAKMmgYCRWPALVTMDPa--cGLSCEWDIDGe----------PQVYHVEYLGTKHSHGWIRadk 193 Yesso scallop
KOF63966     146 GVVFVYPYLTPGDLVMAIMagYCWWPAVVSFDPf--cNGYVEYQEEEqrkhqeveeivVDSYHVEFLGTPRSHAWISssc 223 Octopus bimacul...
XP_022102337  23 GYRYIFSQLPQGSLVWAKMtgHVSWPAILSPDPad-gRYTMINDETGt----------PSHYHVEFLGHPHSHCWVLssn 91  crown-of-thorns...
RUS73803     106 KLDLIKSEIKKGSLVWAKMdgYCRWPALVTDDPa--cDMHADGDEGE-----------ILWYHVEFLGTERSHGWVRter 172 eastern emerald...
ELU12943      73 RMRYVATTIKPGSIVLAKLsgFCRWPAIITKDPie-dGRSAFEDTSGe----------AFSYHVEFFGESHSHSWIPa-- 139 Capitella teleta
XP_013074222  28 KLDLIKSELRVGALVWAKVkgYCRWPAIVTEDPl--nHLHGEWDNFE-----------MISYHVEFLGNNRSHGWVRt-- 92  Biomphalaria gl...
XP_019851023 105 KTGWLYDGFVPGELVWAKLsaYPPWPSIITRDP----WCSNTYVSEEd---------vGLLYHVEFLGRTRSHCWLPq-- 169 Amphimedon quee...
XP_012562080  68 GETIICSELSIGELVWAKMpgYPRWPAVITADPieenGAHIDLYKDGtg--------dPHYYHVEFLGKPRSHAWILa-- 137 Hydra vulgaris
CBY09812      91 GLTYVYSNMLEGTLVQAKLtgFTAWPAIICNDPi--eGNFFDTNENGn----------PTKYHVEFLGKRHTQAWVEa-- 156 Oikopleura dioica

Feature 1                                                                                       
Q504Y3       154 --------tFVGHYSITLKPEkc-----------------------------kNKKKWYKSALQEACLLyGYSHEQRLE 195 human
XP_021376337 194 ------ltlYGHKEEDNPQKRkcrtkqmvrt------------maankiqrrkYQKVPVDLAVMEADELfHLNEDQRLA 254 Yesso scallop
KOF63966     224 idlldsnplSLVSKKYMPKNKgrk---------------------------siFRGNSIEGALKEAEIFqKLSKSVRLK 275 Octopus bimaculo...
XP_022102337  92 ------vdiYGSSSSSQPQKPkhckkslgvs------------agchtaqkvnLYTKNLRESIQEAEPLrALTCEQRLA 152 crown-of-thorns ...
RUS73803     173 vqvfgtnldMIETEKAKTTTNstkrgrkkgkfkrt-----vktigtgklkktyKGGTTIQKAVSEALSLlPLPVDERIN 246 eastern emerald ...
ELU12943     140 --------hSVTSFNPETYKLsdetgqknkfqkastg-ivhtnsvyltgffieERSKGVAYALEEAKEWqKSSFAERLE 209 Capitella teleta
XP_013074222  93 --------nCIEVFGPGNVDRlpvkksqnhkktkkrksiratvtsklnekssfKGLATVNEAIAEAMELlSLPCEERLK 163 Biomphalaria gla...
XP_019851023 170 --------eMVVPYEENCIIGgsktc----------------------prhnfRHDKRIQYAISEADTMtSLSNEERLG 218 Amphimedon queen...
XP_012562080 138 --------rCIEKYSIASTDLffdak----------------------ikdskKIKDRLQYANQEASLMlTLSPKKRLQ 186 Hydra vulgaris
CBY09812     157 --------rSTVNYAGIPKEPpskn------------------------gklkKMPQALIDAYFEAEDLrGLTNEDRLE 203 Oikopleura dioica

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