Conserved Protein Domain Family
PWWP_ZCWPW1
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cd20145: PWWP_ZCWPW1 
PWWP domain found in zinc finger CW-type PWWP domain protein 1 (ZCWPW1) and similar proteins
ZCWPW1 is a histone H3K4me3 reader. It is associated with late-onset Alzheimer's disease (LOAD). In addition to the PWWP domain, ZCWPW1 contains a zinc finger CW (zf-CW) domain that is a histone modification reader for the histone H3 tail with trimethylated K4. The PWWP domain specifically recognizes DNA and histone methylated lysines.
Links
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Statistics
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PSSM-Id: 438973
Aligned: 61 rows
Threshold Bit Score: 126.895
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Feature 1:putative methyl-histone binding site [polypeptide binding site]
Evidence:
  • Comment:the aromatic residues form the three-walled methyl-lysine cage that directly participate in histone methylated lysine binding and recognition.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #  #                                 #                  
Q9H0M4        310 VAYASYIPGSIIWAKQYG------YPWWPGMIESDPDl-GEYFLFTSHld--slPSKYHVTFFGe--TVSRAWIPvNMLK 378  human
OQR80047       86 FYHPEFFPGNVVWAQKDKdsvgsgPHWWPALIEDGHDrrSQFFLLGANkspesrPIAYHVTFLDt--WRSGGWVGaHRVH 163  Tropilaelaps ...
XP_026694135  273 FVYTEYNAGSIVWAKMAG------YPPWPAMVDSDPDt-DMLYEYDEEg----aVLRYHVVFLDk--NVSRAWIPsRCIE 339  vase tunicate
XP_023345088  211 LVDVEYALGSLVWAKFRG------FPWWPGLVDYCPEk-EETLLLDPEtn---qPQQYHVVFFDkgqNVSRSWVYrEDIC 280  Eurytemora af...
XP_015917172   93 EDYLEFCPGSLVWAKLDG------YPWWPAMVDEDPDi-EEFFLSQRK------SDYYHVTFLDe--KVSRAWIRtTQIS 157  common house ...
GBM46496       81 EHYLEYSPGSVVWAKLEG------YPWWPAMVDEDPDv-EEFSWREKG------DLHYNVTFLDe--KPTRAWIPeMFIC 145  Araneus ventr...
XP_018917451  685 LIETKFTAGSVVWARVVG------YPFWPAMVEDDPDy-DQFYWCHDRdp--qkVTQYHVTFFDt-kAVTRSWVTtPSVK 754  Bemisia tabaci
GBM25430       97 YVDEDYTPGSLVWAKMDG------HPNWPAMVEDDPDe-EEYCKDLET------DAKYHVVFLGd--PPSRRWINaKRLV 161  Araneus ventr...
GBM88863       85 FAREKYPPGAMVWAKLPG------FDWWPAMIEDSPDt-QEFFVTLGNg-----VEEYHVTFFGk--SPKRSWIKaSHIR 150  Araneus ventr...
XP_003741564   90 FYETKYCAGSLVWAKRPDnhkekeWRWWPALVEDSPDpaSQYFLLDGIse---iPIAYHVTFLDa--YRTCGWVRsDLLK 164  western preda...

Feature 1                                                              
Q9H0M4        379 NFQElslelsv-----mkkrrndCSQKLGVALMMAQEAEQIs-IQERVNLFGF 425  human
OQR80047      164 PFIDdavelvnfqkqksvaavpkRARLLTEAIERARNALRTkdITNRLELFSF 216  Tropilaelaps mercedesae
XP_026694135  340 PYNHsnnqln-------lcnekhFKSELNTAITAADEALTMs-LAKRIEKFSF 384  vase tunicate
XP_023345088  281 KLTDvnhpprr-----pafkketVRQRYNLAKKMAKEALALd-LIERVEKFSF 327  Eurytemora affinis
XP_015917172  158 SYLKpphmhrhl---pkhlnrkkYRMLLEKAEVNANAALEMt-LKERLEKFSF 206  common house spider
GBM46496      146 PFLKppkkekrc---vqkfrrnrYAKAISKAKERAETAMKMt-IKDRLQTYSF 194  Araneus ventricosus
XP_018917451  755 AFTEldnptkr-----ltgknacYASRINEAKKEASIALKLt-NSERLAKCSF 801  Bemisia tabaci
GBM25430      162 PFKMpisnev--------grkrfRGKRLAFAVEEAERAFKMt-KQNRLLTFSL 205  Araneus ventricosus
GBM88863      151 EYAPdtsn-----------kpskGSSTLRKSIEQAEEAAKLp-IKERLKKFSF 191  Araneus ventricosus
XP_003741564  165 PFRArsknvvki----sasrtggKRSLLNEAVIRAREAAKId-VIRRLEKFSY 212  western predatory mite

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