4LD6


Conserved Protein Domain Family
PWWP_PWWP2
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cd20140: PWWP_PWWP2 
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PWWP domain found in the PWWP domain-containing protein 2 (PWWP2) family
The PWWP2 family includes PWWP2A and its paralog PWWP2B. PWWP2A is a H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. It is also required for proper mitosis progression. PWWP2A and PWWP2B form a stable complex with NuRD subunits MTA1/2/3:HDAC1/2:RBBP4/7, but not with MBD2/3, p66alpha/beta, and CHD3/4. The PWWP domain specifically recognizes DNA and histone methylated lysines.
Links
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Statistics
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PSSM-Id: 438968
Aligned: 24 rows
Threshold Bit Score: 126.608
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:putative methyl-histone binding site [polypeptide binding site]
Evidence:
  • Comment:the aromatic residues form the three-walled methyl-lysine cage that directly participate in histone methylated lysine binding and recognition.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #  #                                          #                 
4LD6_A         12 GRTVAVGDIVWGKIHGFPWWPARVLDISlgqke-----------------dgepsWREAKVSWFG-SPTTSFLSISKLSP 73   human
XP_001624451  437 AASINEGSIIWGKVHGHPWWPGRVMAITevvdd------------------qggvDTFAHVTWFG-SNTSSEMPVQELQD 497  starlet sea a...
RDD38785      344 CRTFQVGDIVWGKVQGHPWWPGRIVSLDatvee------------------qhlyPCKAVVAWYN-SNTCSIISARRLYD 404  Trichoplax sp...
ELU07008       12 GTTFQCGSIAWAKIVGCPWWPCRVRTFVktenp------------------eggaTYTANVSWFA-TKTFSMVDCTDMRP 72   Capitella teleta
GAU94354      452 NRHFAVGDVVWGKITGYPWWPGIIRHIVicddpvlqktaiapslsgsratssflqYQEAQVEWYGqKSSISYIEVGQLAH 531  Ramazzottius ...
XP_002131293  387 NGVFTQGDVVWGKLRGYPWWPSKITKLTttkid------------------gkilQQHAEVGWFQ-CRTRSVIPIRNVQL 447  vase tunicate
XP_014661539  393 GKTLAVGDVVWGKIHGFPWWPGHVIGISestrd-----------------ngslvRQLAHVAWFA-STTSSTMSCSELLS 454  Priapulus cau...
VDL88659      576 GSVFRLGDIVWCKLSGWPFWPARITSIAke-----------------------esTCTACVRWFA-WDQVSYMACDKLWP 631  Schistocephal...
XP_021956291  910 NQVYRKGDVVWGKSTGCPWWPGKIVDIQlrg----------------------vtDVRAKLAWYR-SSTQSCITLSDLHP 966  Folsomia candida
XP_023345802  344 GLTLRRGDVVWARQGRKPYWPAKIIHLLlledrv----------------npelkIQHAQVSWYT-SVTTSVLPSANLAP 406  Eurytemora af...

Feature 1                                        
4LD6_A         74 FSEFFklr-fnRKKKGMYRKAITEAANAARH 103  human
XP_001624451  498 FEPNFrrr-ykKDKKGCYRRAVRQAQETLTI 527  starlet sea anemone
RDD38785      405 FDESYdlr-hmPKRRGAYQKAVEDALLASRQ 434  Trichoplax sp. H2
ELU07008       73 FLEDFhlrytrKQRKSGYRSAVRNALAVAKL 103  Capitella teleta
GAU94354      532 FAEDFerk-ykPKLRGAYQEAVTLAKQAVNE 561  Ramazzottius varieornatus
XP_002131293  448 FQKHFhdr-feKRRKGGYQKAVAAAHEALKE 477  vase tunicate
XP_014661539  455 FIENFhgr-fnKKKKGSYKEAVRQAMLAAQA 484  Priapulus caudatus
VDL88659      632 FLEHYdkkldrRKKRGAYKQAVDQALEAARS 662  Schistocephalus solidus
XP_021956291  967 FEEYFdikytkNRKRGFYQQAVREALIDAHQ 997  Folsomia candida
XP_023345802  407 FLDKYeni-fhKRRKGAYKTAVKLAADDARG 436  Eurytemora affinis

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