Conserved Protein Domain Family
MBT_L3MBTL4_rpt3
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cd20139: MBT_L3MBTL4_rpt3 
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4)
L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439129
Aligned: 5 rows
Threshold Bit Score: 173.129
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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methyllysine
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of MBT domains with bound methylated lysine peptides or chemical probes
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          #  #  # #               #  #   #                              
Q8NA19       288 FKMRLPHGFLPNMKLEVVDKRNPRLIRVATIVDVDDQRVKVHFDGWDHKYDYWVEADSPDIHPIGWCDVTGHPLEVPQRT 367 human
NP_001089886 332 FKPRPPHGYQPHMKLEAVDQRNPTLIRVCSTVDKDDNRIKLHFDGWSSLYDFWVDVDSPDIHPVGWCAKTGHALQLPPGA 411 African clawed ...
XP_006005445 457 FKLRPPHGFQVNTKLEAVDKRNPILIRVATIVDRDDHRIKLHFDGWNHNYDYWVDADSFDIHPVGWCSKTGHPLQLPLGY 536 coelacanth
XP_012426045 336 FKLRPPHGFQVNTKLEAVDRRNPILIRVATIIDKDSHRIKIHFDGWDHDYDFWVDADSPDIHPVGWCDKTGHALQVPRGA 415 zebra finch
XP_015153233 293 FKLRPAHGFQVNMKLEAVDKRNPILIRVATITDRDDHRIKIHFDGWDCNYDFWVDADSPDVHPVGWCAKTGHALQVPLGA 372 chicken

Feature 1          
Q8NA19       368 ND 369 human
NP_001089886 412 SD 413 African clawed frog
XP_006005445 537 SD 538 coelacanth
XP_012426045 416 ED 417 zebra finch
XP_015153233 373 VD 374 chicken

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