4L59,4FL6,1WJQ


Conserved Protein Domain Family
MBT_L3MBTL3_rpt3
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cd20138: MBT_L3MBTL3_rpt3 
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third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439128
Aligned: 8 rows
Threshold Bit Score: 166.64
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyllysine
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of MBT domains with bound methylated lysine peptides or chemical probes
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          #  #  # #               #  #   #                            
4L59_A       240 FKVKPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPL 317 human
4FL6_A       240 FKVKPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPL 317 human
1WJQ_A         6 SGVKPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPL 83  human
Q96JM7       467 FKVKPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPL 544 human
NP_001232893 437 FKVKPPHGFQVNMKLEVVDKRNPVLIRVATVADTDDHRLWIHFDGWTDEYDYWIDADSPDVHPAGWCAKTGHPLQPPI 514 zebrafish
XP_014352270  26 FKVKPPHGFQKNMKLEVVDKRNPVLIRVATIVDTEDHRIKIHFDGWNKDYDYWIDADSPDLHPAGWCAKTGYPLQPPI 103 coelacanth
XP_007897437 458 FKSRPPHGFQPNMKFEVVDKRNPMLIRVATILDVDDHRIKVHFDGWNHDYDYWIDADSPDIHPAGWCAKIGHPLQPPI 535 elephant shark
EMP34840     541 SLQKPSHGFQKNMKLEVVDKRNPVLIRVATVVDIDDHRIKVHFDGWDSIYDYWTDADSPDIHPAGWCAKTGHPLQPPL 618 Green sea turtle

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