3OQ5,1OYX,1OZ2,2PQW,2RHI,2RHY


Conserved Protein Domain Family
MBT_L3MBTL1_rpt3
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cd20137: MBT_L3MBTL1_rpt3 
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third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439127
Aligned: 15 rows
Threshold Bit Score: 159.606
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyllysine
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
  • Structure:2RHI; Homo sapiens L3MBTL1 binds tetraethylene glycol at the methyllysine binding site of its fourth MBT repeat, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #  #  # #               #  #   #                             
3OQ5_A       260 PPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLG 334 human
2RHI_A       254 PPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLG 328 human
2RHY_A       245 PPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLG 319 human
E1C2V1       539 PPHGFLVNMKLEAVDRRTPSFIRVASVEDVEDHRIKIHFDGWSHVYDFWIDADHPDIHPIGWCSKTGHPLQPPLR 613 chicken
Q9Y468       513 PPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLG 587 human
XP_023660798 548 PPHGFQVQVKLEAVDKRSPALIRVATVEEVDTHRIKIHLDGWSHMYDEWMDADHPDLHPAGWCEHTGHPLQPPLC 622 Paramormyrops kingsl...
XP_007883032 544 PPHGFQINMKLEAVDRRNSMLIRVATIVDVDDHRIKIHFDGWSHVYNYWVDADNPDIHPVGWCARTGYPLHPPVK 618 elephant shark
XP_004918599 465 PPHGFKVDMRLEAVDRRSPSLICVASVVEVEEFRIKVHFDGWSHMYDFWLDADHPDLHPAGWSQRTGHPLQTPLR 539 western clawed frog
XP_018093897 474 PPHGFKVDMRMEAVDRRSPSLIRVSSVVEVEEFRIKVHFDGWSHMFDFWLDADHPDLHPAGWCQRTGHPLQTPLR 548 African clawed frog
XP_014342931 277 PSHGFQVNMKLEAVDRRNLSLIRVASVEEVEDYRIKIHFDGWSHAYDYWVDSDHPDIHPVGWCSKTGHPLQPPIR 351 coelacanth

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