Conserved Protein Domain Family
MBT_L3MBTL4_rpt2
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cd20136: MBT_L3MBTL4_rpt2 
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4)
L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439126
Aligned: 4 rows
Threshold Bit Score: 206.007
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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methyllysine
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on structures of MBT domains with bound methylated lysine peptides or chemical probes
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #  #  # #               #  #   #                                  
Q8NA19       188 MSKEFQVGMKLEAVDRKNPsLVCVATIADIvEDRLLVHFDNWddSYDYWCDVN-----SPYVQPVGWCQEnGRTLIAPQG 262 human
B1B1A0       188 VPREFQVGMKLEAVDRRNPcLMCVATIADIvEDRVRVHFDSLddSFDYWCDVN-----SPYIQPVGWCQEnGRTLVAPQG 262 house mouse
XP_004579779 152 MPKEFRVGMKLEAVDRKNPsLVCVATIADIvEDRLLVHFDSWddSYDYWCDVN-----SPYVQPVGWCQKnGRTLVAPQG 226 American pika
XP_012507528   1 MPKEFQVGMKLEAVDRKNPsLVCVATIADIvEDRLLVHFDNWddSYGYWXDTNvfyfcSPDIHPVGWCEKtKHKLHIPKG 80  Coquerel's sifaka

Feature 1                         
Q8NA19       263 YpnpENFSWTEYLEATQ 279 human
B1B1A0       263 YphpDKFSWTDYLRASQ 279 house mouse
XP_004579779 227 YpnpEKFSWTEYLEATQ 243 American pika
XP_012507528  81 YpdpENFSWTEYLEATQ 97  Coquerel's sifaka

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