4FL6,4L59,3UT1


Conserved Protein Domain Family
MBT_L3MBTL3_rpt2
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cd20135: MBT_L3MBTL3_rpt2 
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second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439125
Aligned: 14 rows
Threshold Bit Score: 194.637
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyllysine
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
  • Structure:4FL6; Homo sapiens L3MBTL3 binds UNC1215, a potent and selective chemical probe for methyllysine; contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  #  # #               #  #   #                                 
4FL6_A       139 VIPSGFRVGMKLEAVDKKNPsFICVATVTDMvDNRFLVHFDNWdeSYDYWCEAsSPHIHPVGWCKEhRRTLITPPGYpnv 218 human
4L59_A       139 VIPSGFRVGMKLEAVDKKNPsFICVATVTDMvDNRFLVHFDNWdeSYDYWCEAsSPHIHPVGWCKEhRRTLITPPGYpnv 218 human
3UT1_A       139 VIPSGFRVGMKLEAVDKKNPsFICVATVTDMvDNRFLVHFDNWdeSYDYWCEAsSPHIHPVGWCKEhRRTLITPPGYpnv 218 human
Q96JM7       366 VIPSGFRVGMKLEAVDKKNPsFICVATVTDMvDNRFLVHFDNWdeSYDYWCEAsSPHIHPVGWCKEhRRTLITPPGYpnv 445 human
XP_006005445 356 VTPSGFRVGMKLEAVDRKNPtLMCVATIADMvDNRLLIHFDNWdqSYDYWCDAsSPYIRPVGYCQEaGLPLTTPPDYkdp 435 coelacanth
XP_012426047 124 VTPSGFRLGMKLEAVDKKNPsLVCVATITDMvENRLLIHFDNWdeSYDYWCETsSPYIRPVGYCQEtGTPLTTPPGHrds 203 zebra finch
XP_004911641 341 VTPSGFRAAMKLEAVDRKNPsLLCVATISDIvENRLLIHFDSWdhSYDYWCDAsSPYIRPVGYCQEsAIALTPPPEYkdp 420 western clawed ...
XP_015153234 154 VTPSGFRLGMKLEAVDKKHPsLMCVATISDMvDNRLLIHFDNWdeTYDYWCESsSPYIRPVGYCQEtGTPLTTPPGYkdp 233 chicken
XP_025004861 210 VIPSGFRVGMKLEAVDKKNPtFVCVATVTDMvDNRFLVHFDNWdeSYDYWCEAaSPHIHPVGWCKEhKRTLITPPDYpha 289 chicken
NP_001089886 231 VTPSGFRVGMKLEAVDRKNPsLLCVATIADIvENRLLIHFDSWdhSYDYWCDAsSPYIRPVGYCQEsSITLTPPPEYkdp 310 African clawed ...

Feature 1                     
4FL6_A       219 KHFSWDKYLEETN 231 human
4L59_A       219 KHFSWDKYLEETN 231 human
3UT1_A       219 KHFSWDKYLEETN 231 human
Q96JM7       446 KHFSWDKYLEETN 458 human
XP_006005445 436 KRFSWERYLGETA 448 coelacanth
XP_012426047 204 KAFSWEKYLEETN 216 zebra finch
XP_004911641 421 KCFTWEAYLEKNG 433 western clawed frog
XP_015153234 234 KAFSWEKYLVETN 246 chicken
XP_025004861 290 KHFSWEKYLEETS 302 chicken
NP_001089886 311 KTFSWEAYLEKTG 323 African clawed frog

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