2PQW,1OYX,2RHI,2RHU,2RHZ,2RI5


Conserved Protein Domain Family
MBT_L3MBTL1_rpt2
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cd20134: MBT_L3MBTL1_rpt2 
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second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439124
Aligned: 14 rows
Threshold Bit Score: 200.831
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyllysine
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
  • Structure:2PQW; Homo sapiens L3MBTL1 in complex with H4k20me2 peptide through its second MBT repeat, contacts at 4A
  • Structure:2RHI; Homo sapiens L3MBTL1 in complex with H1.5k27me2 through its second MBT repeat, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  #  # #               #  #   #                                 
2PQW_A       141 PPPLGFQVGMKLEAVDRMNPsLVCVASVTDVvDSRFLVHFDNWddTYDYWCDPsSPYIHPVGWCQKqGKPLTPPQDYpdp 220 human
1OYX_A       144 PPPLGFQVGXKLEAVDRXNPsLVCVASVTDVvDSRFLVHFDNWddTYDYWCDPsSPYIHPVGWCQKqGKPLTPPQDYpdp 223 human
2RHI_A       149 PPPLGFQVGMKLEAVDRMNPsLVCVASVTDVvDSRFLVHFDNWddTYDYWCDPsSPYIHPVGWCQKqGKPLTPPQDYpdp 228 human
2RI5_A       140 PPPLGFQVGMKLEAVDRMAPsLVCVASVTDVvDSRFLVHFDNWddTYDYWCDPsSPYIHPVGWCQKqGKPLTPPQDYpdp 219 human
E1C2V1       434 EAPPGFEVGMKLEAVDRMNPsLICVATVTDVvDDRFLVHFDNWddTYDYWCDPsSPYIHPVGWCQEhGKPLTPPQDYpdp 513 chicken
Q9Y468       408 PPPLGFQVGMKLEAVDRMNPsLVCVASVTDVvDSRFLVHFDNWddTYDYWCDPsSPYIHPVGWCQKqGKPLTPPQDYpdp 487 human
XP_007883032 439 VIPLGFRVGMKLEAVDRMNPsLICVATVTDIvDNRFLVHFDNWddTYDYWCDAsSPYIHPVGWCQEhGKTLTPPQGHphp 518 elephant shark
XP_014342931 172 MTPTGFRVGMKLEAVDRMNPsLICVATVTDVvDNRFLVHFDNWddTYDYWCDAsSPYIHPIGWCQDiGKPLTPPQGYpsp 251 coelacanth
OCT60570     357 APPSLFRVGMKLEAVDRMNPsLICVASVTDViEDRFLVHFDNWgdTYDYWCDPsSPYVHPVGWCQQhKKPLTPPQDYpdp 436 African clawed ...
XP_002666454 396 ETDCGFEVGMKLEAVDRMNPsLICVATVTDRvADRFLVHFDNWddTYDYWCDSsSPYIHPIGWCHErGLPLTPPQDYpev 475 zebrafish

Feature 1                     
2PQW_A       221 DNFCWEKYLEETG 233 human
1OYX_A       224 DNFCWEKYLEETG 236 human
2RHI_A       229 DNFCWEKYLEETG 241 human
2RI5_A       220 DNFXWEKYLEETG 232 human
E1C2V1       514 DNFIWEKYLKETG 526 chicken
Q9Y468       488 DNFCWEKYLEETG 500 human
XP_007883032 519 EHFSWDKYLEGTG 531 elephant shark
XP_014342931 252 ENFTWEKYLEETG 264 coelacanth
OCT60570     437 EGFSWDKYLLETK 449 African clawed frog
XP_002666454 476 DRFSWERYLEETG 488 zebrafish

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