4C5I,3FEO,6NFX


Conserved Protein Domain Family
MBT_MBTD1_rpt4
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cd20129: MBT_MBTD1_rpt4 
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fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1)
MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439119
Aligned: 10 rows
Threshold Bit Score: 163.996
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyllysine
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of MBT domains with bound methylated lysine peptides
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #  #  # #               #  #   #                           
4C5I_A       364 HGFRVGMKLEAVDLMEPRLICVATVTRIiHRLLRIHFDGWEeEYDQWVDCESPDLYPVGWCQLTGYQLQPP 434 human
3FEO_A       361 HGFRVGMKLEAVDLMEPRLICVATVTRIiHRLLRIHFDGWEeEYDQWVDCESPDLYPVGWCQLTGYQLQPP 431 human
6NFX_A       352 HGFRVGMKLEAVDLMEPRLICVATVTRIiHRLLRIHFDGWEeEYDQWVDCESPDLYPVGWCQLTGYQLQPP 422 human
Q32N90       513 HGFRVGMKLEAVDLMEPRLVCVATVTRIiHRLLRIHFDGWEdEYDQWVDCESPDLYPVGWCQLTGYQLQPP 583 African clawed frog
XP_007907366 491 HGFRIGMKLEAVDLMEPRLVCVATVTRIvHRLLRIHFDGWEdEYDQWVDCESSDLYPIGWCELTGYQLQPP 561 elephant shark
Q05BQ5       490 HGFRVGMKLEAVDLMEPRLICVATVTRIiHRLLRIHFDGWEeEYDQWVDCESPDLYPVGWCQLTGYQLQPP 560 human
XP_009909783 490 HGFHVGMKLEAVDLMEPRLVCVATVTRIiHRLLRIHFDGWEeEYDQWVDCESPDLYPVGWCQLTGYQLQPP 560 Downy woodpecker
PWA14130     208 HGFRIGMKLEAVDLMEPRLVCVATVTRIvHRLLRIHFDGWEdEYDQWVDCESPDLYPVGWCQLTGYQLQPP 278 western mosquitofish
XP_015150851 493 HGFHVGMKLEAVDLMEPRLVCVATVTRIiHRLLRIHFDGWEdEYDQWVDCESPDLYPVGWCQLTGYQLQPP 563 chicken
XP_006001284 515 HGFKVGMKLEAVDLMEPRLVCVATLTRIvHRLLRIHFDGWEdEYDQWVDCESPDLYPVGWCQLTGYPLQPP 585 coelacanth

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