3FEO,4C5I,6NFX


Conserved Protein Domain Family
MBT_MBTD1_rpt3
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cd20126: MBT_MBTD1_rpt3 
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third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1)
MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439116
Aligned: 16 rows
Threshold Bit Score: 194.622
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3FEO_A        255 FKEGMKLEAIDPLNlsTICVATIRKVLaDGFLMIGIDGSeaadgSDWFCYHAtSPSIFPVGFCEInMIELTPPRGYtklp 334  human
Q32N90        407 FKEGMKLEAIDPLNlsAICVATIRKVLaEGYLMIGIDGSeaadgSDWFCYHAsSPSIFPVGFCEInKIELTPPRGYtklp 486  African clawe...
XP_006001284  409 FREGMKLEAIDPLNlsAICVATVRKVLaDGYLMIGIDGSeaadgSDWFCYHAtSPSIFPVGFCEInMIELTPPRGYiklp 488  coelacanth
XP_013400962  455 FEAGMKLEAIDPLNlsTICVASVMKVLkNNYLMIGIDGSmahngSDWFCYHAsSPSIFPMGFCEInSIELTPPRGYkg-p 533  Lingula anatina
EKC25175      388 FQVGMKLEAIDPLNlsAICVATVMKVLkNNYLMIGIDGSmaengSDWFCYHAtSPCIFPVGFCKInGLDLTPPRGHkg-p 466  Pacific oyster
ELT89486      334 FQAGMKLEAIDPLNlsTICVATVMKVLrNNYLMIGIDGSmaadgSDWFCYHStSPCIFPVGFCELnQIVLTPPRGFkt-t 412  Capitella teleta
XP_007907367  408 YQEGMKLEAIDPLNlsAICVATVRKVLaEGYLMIGIDGSeaadgSDWFCYHStSPSVFPVGFSEInKIELTPPRGYtklp 487  elephant shark
XP_006815581  407 FEVGMKLEAIDPLNlaNICVATVMKVLkNSYLMIGIDGSmavdgSDWFCYHAtSPCVFPAGFCELnSIDLTPPRNYkg-k 485  Saccoglossus ...
XP_019625155  403 FHVGMKLEAIDPLNlsTVCVATVRKVLrEGYLMIGIDGMetpdgSDWFCYHQtSANIFPVGFCDLnKIELTPPRSYsa-p 481  Belcher's lan...
PWA14130      102 FKDGMKLEAIDPLNlsAICVATVKKVLaDGYLMIGIDGSeaidgSDWFCYHAmSPSIFPVGFCEInNIELTPPKGYtklp 181  western mosqu...

3FEO_A        335 FKWFDYLRETG 345  human
Q32N90        487 FKWFDYLRETG 497  African clawed frog
XP_006001284  489 FKWFDYLRETG 499  coelacanth
XP_013400962  534 FKWFDYLKQTK 544  Lingula anatina
EKC25175      467 FKWFDYLKQTK 477  Pacific oyster
ELT89486      413 FRWIDYLRETK 423  Capitella teleta
XP_007907367  488 FKWFDYLREMG 498  elephant shark
XP_006815581  486 FKWLDYLMATK 496  Saccoglossus kowalevskii
XP_019625155  482 FKWLDYLKKTK 492  Belcher's lancelet
PWA14130      182 FKWFDYLRETG 192  western mosquitofish
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