first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins
L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.
Feature 1:Pho/YY1 spacer binding site [polypeptide binding site]
Evidence:
Comment:based on the structures of other dSfmbt family members with bound transcriptional regulators Pho/YY1 spacer regions
Comment:Pho/YY1 transcriptional regulators contain an N-terminal highly conserved spacer region (also known as the REPO domain), a novel interacting motif that tightly binds to dSfmbt family proteins
Jiyao W et al.(2023). "The conserved domain database in 2023.",