4C5I,3FEO,6NFX


Conserved Protein Domain Family
MBT_MBTD1_rpt1
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cd20120: MBT_MBTD1_rpt1 
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first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1)
MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.
Links
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Statistics
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PSSM-Id: 439110
Aligned: 12 rows
Threshold Bit Score: 226.27
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Pho/YY1 spacerputative
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:Pho/YY1 spacer binding site [polypeptide binding site]
Evidence:
  • Structure:4C5I; Homo sapiens MBTD1 binds transcriptional repressor protein YY1 spacer region through its first MBT repeat; contacts at 4A
  • Comment:Pho/YY1 transcriptional regulators contain an N-terminal highly conserved spacer region (also known as the REPO domain), a novel interacting motif that tightly binds to dSfmbt family proteins
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                         ##  ## ####     
4C5I_A         43 WGDISENVRVEVPNTDCslptkVFWIAGIVKLaGYNALLRYEGFEn-DSGLDFWCNIcGSDIHPVGWCAAsGKPLVPPRT 121  human
3FEO_A         40 WGDISENVRVEVPNTDCslptkVFWIAGIVKLaGYNALLRYEGFEn-DSGLDFWCNIcGSDIHPVGWCAAsGKPLVPPRT 118  human
6NFX_A         31 WGDISENVRVEVPNTDCslptkVFWIAGIVKLaGYNALLRYEGFEn-DSGLDFWCNIcGSDIHPVGWCAAsGKPLVPPRT 109  human
XP_021336055  192 WGDIAEGLRVEVFNSDTnlstkVYWVAEIVKLaGFKALLRYEGFDn-DSSRDFWCNLcIPEIHPVGWCASsGKPLVPPKS 270  zebrafish
Q32N90        192 WGDIAEGVRIEVPNTDSnlptkVFWISGIVKLaGYNALLRYEGFEn-DSSLDFWCNIcGPDIHPVGWCATsGKPLVPPQS 270  African clawe...
XP_006001285    5 WGDISEGVRLEVPNTDCnlptkVFWIAGIVKLaGYKALLRYEGFDs-DSSLDFWCNIcGSDVRPVGWCATsGKPLVPPRT 83   coelacanth
XP_007907367  193 WGDIAEGVRVEVPNTDSnlptkVFWIAAIIKLaGYKALLRYEGFDs-DSSLDFWCNIcGSDIHPVGWCATsGKPLVTPRT 271  elephant shark
XP_002598162  176 WSDVAVGMKVEVLNTDCdlpskVFWIAQVIKIaGYRAKLRYEGFEe-NSSLDFWCNLcTMEVHPVGWCATiGKPLVPPKT 254  Florida lancelet
XP_009860864  122 WSEIEKGVKVEVLNLDCpvptkVYWIAQVIKVaGYKALLRYEGFGdtDSRCDFWCNLcTHDVHAVGWCATiGKPLVPPKT 201  vase tunicate
XP_006815581  185 WEDIAVGMKVEVLNTDCdlpnhVFWIAQVVKIaGYKALLRYEGFGs-DKSHDFWCNLmRMDVHPVGWCATiGKPLLPPKS 263  Saccoglossus ...
Q05BQ5        169 WGDISENVRVEVPNTDCslptkVFWIAGIVKLaGYNALLRYEGFEn-DSGLDFWCNIcGSDIHPVGWCAAsGKPLVPPRT 247  human
KFQ17932      169 WGDISEGVRVEVPNTDCslptkVFWIAGIVKLaGYNALLRYEGFEn-DSSLDFWCNIcGSDIHPVGWCATsGKPLVPPRT 247  carmine bee-e...

Feature 1                 #  ##  #########
4C5I_A        122 IqhKYTNWKAFLVKRLTGAKTLPP 145  human
3FEO_A        119 IqhKYTNWKAFLVKRLTGAKTLPP 142  human
6NFX_A        110 IqhKYTNWKAFLVKRLTGAKTLPP 133  human
XP_021336055  271 IqhKYSNWKAFLVKRLTGAKTLPP 294  zebrafish
Q32N90        271 IqhKYTNWKAFLVKRLTGAKTLPP 294  African clawed frog
XP_006001285   84 IqhKYTNWKAFLVKRLTGAKTLPP 107  coelacanth
XP_007907367  272 IhhKYTNWKAFLVKRLTGAKTLPP 295  elephant shark
XP_002598162  255 IqhKYTNWKGFLVKRLTGAKTLPG 278  Florida lancelet
XP_009860864  202 IqfKYSNWKSFLVQRLTGAKTLPN 225  vase tunicate
XP_006815581  264 IasRRSNWRTFLVNSLTGAKTLPS 287  Saccoglossus kowalevskii
Q05BQ5        248 IqhKYTNWKAFLVKRLTGAKTLPP 271  human
KFQ17932      248 IqhKYTNWKAFLVKRLTGAKTLPP 271  carmine bee-eater

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