first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins
dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.
Feature 1:Pho/YY1 spacer binding site [polypeptide binding site]
Evidence:
Comment:Pho/YY1 transcriptional regulators contain an N-terminal highly conserved spacer region (also known as the REPO domain), a novel interacting motif that tightly binds to dSfmbt family proteins
Structure:4C5E: Drosophila melanogaster Sfmbt binds transcriptional regulator Pho spacer region through its first MBT repeat; contacts at 4A
Structure:4C5E; Drosophila melanogaster Sfmbt forms an octameric (4:4) complex with Polycomb protein Pho; contacts at 4A
Jiyao W et al.(2023). "The conserved domain database in 2023.",