Conserved Protein Domain Family
MBT_SFMBT2_rpt1
?
cd20112: MBT_SFMBT2_rpt1 
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2)
SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.
Links
?
Statistics
?
PSSM-Id: 439102
Aligned: 7 rows
Threshold Bit Score: 218.7
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
putative
Feature 1:putative methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
  • Comment:Not all MBT repeats contain the semi-aromatic cage that facilitate binding to methyllysine residues
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #  #  # #               #  #     #                                 
Q5VUG0         71 QSNFQPGMKLEVANKNNpdTYWVATIITTCGQLLLLRYCGYGedrRADFWCDVvIADLHPVGWCTQnNKVLMPPDAIkeK 150  human
XP_683042      37 QSSFQPGMKLEVANKGSvdTYWVATIITTCGQLLLLRYCGYGedrKADFWCDVmTAELHPVGWCAQnDKTLQPPEAIkeK 116  zebrafish
XP_014342653   84 QSSFQPGMKLEVANKSNpdTYWVATIITTCGQLLLLRYSGYGddrKADFWCDVmTADLHPVGWCTQnNKVLMPPEAIkeK 163  coelacanth
XP_007905839   86 QSSFQPGMKLEVANKNHpdTYWVATIITTCGQLLLLRYSGYGddrRADFWCDVmTADLHPVGWCSQnKKELKPPEAIseK 165  elephant shark
XP_018108239   73 QSSFQPGMKLEVANKSNpdTYWVATIITTCGQLLLLRYCGYGedrKADFWCDVmTANLHPVGWCTQnNKLLMPPDAIkeE 152  African clawe...
XP_009488526   73 QSSFQPGMKLEVANKSNpdTYWVATIITTCGQLLLLRYCGYGddrRADFWCDVmTADLHPVGWCTQnNKVLMPPDAIkeK 152  Pelecanus cri...
XP_025009086   73 QSSFQPGMKLEVANKSNpdTYWVATIITTCGQLLLLRYCGYGddrRADFWCDVmTADLHPVGWCTQnSKVLMPPDAIkeK 152  chicken

Feature 1                       
Q5VUG0        151 YTDWTEFLIRDLTG 164  human
XP_683042     117 YSDWTEFLIKELTG 130  zebrafish
XP_014342653  164 HNDWTEFLIQDLTG 177  coelacanth
XP_007905839  166 YTDWTEFLIQDLTG 179  elephant shark
XP_018108239  153 CTDWAEFLIHDLTG 166  African clawed frog
XP_009488526  153 YMDWTEFLIHDLTG 166  Pelecanus crispus
XP_025009086  153 YVDWTEFLIHDLTG 166  chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap