Conserved Protein Domain Family
MBT_SFMBT1_rpt1
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cd20111: MBT_SFMBT1_rpt1 
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1)
SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.
Links
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Statistics
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PSSM-Id: 439101
Aligned: 5 rows
Threshold Bit Score: 194.277
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative
Feature 1:putative methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
  • Comment:Not all MBT repeats contain the semi-aromatic cage that facilitate binding to methyllysine residues
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #  #  # #               #  #     #                                 
Q9UHJ3        47 QNGFAPGMKLEVAVRTDpETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIrKADLYPIGWCEQNKKTLEAPEGIRDK 126 human
XP_014341449  46 QNGFVPGMKLEVANKNDpNTYWVTTIITTCGQLLLLRYDGYGEDRKADFWCDImTADLHPIGWCTQNSKVLRPPEGIKDK 125 coelacanth
XP_015148247  47 QNGFAPGMKLEVAVKSDqNTYWVATIITTCGQLLLLRYDGYGEDRKADFWCDImTADLHPIGWCEQNEKVLKVPEGIKDK 126 chicken
NP_001120258  47 KNGLSPGMRLEVPHGTEsQVYWIANIITTCGKLLLLRYLGCGEDRSADFWCDMvTSDLHPLGWAQQNGKSLRPPEGIREK 126 tropical clawed...
KPP63975      40 QTGLSPGMKLEVPLRDQpDTYWVATIITTCGQLLLLRYEGFQDDRRADFWCDImTADLHPIGWSRQQGRTMKPPEGVREK 119 Asian bonytongue

Feature 1                      
Q9UHJ3       127 VSDWDEFLRQTLIG 140 human
XP_014341449 126 YSDWETFLSQTLQD 139 coelacanth
XP_015148247 127 IPDQEEFLQRVLKG 140 chicken
NP_001120258 127 LQNWEEFLAENSTG 140 tropical clawed frog
KPP63975     120 HEDWEALLEKTLFE 133 Asian bonytongue

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