2R57


Conserved Protein Domain Family
MBT_dScm_rpt2
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cd20110: MBT_dScm_rpt2 
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second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins
Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439100
Aligned: 10 rows
Threshold Bit Score: 160.696
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyllysine
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on structure evidence that Homo sapiens SCML2 binds histone H2A modified peptide through its second MBT repeat.
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  # ## #               #  #   #                         ###
2R57_A       139 PEENLFKVGQKLEAVDKKNPQLICCATVDAIkDDQIHVTFDGWrGAFDYWCNYrSRDIFPAGWCARsCHPMQPPG 213 fruit fly
Q9VHA0       309 PEENLFKVGQKLEAVDKKNPQLICCATVDAIkDDQIHVTFDGWrGAFDYWCNYrSRDIFPAGWCARsCHPMQPPG 383 fruit fly
KOF74556     141 PHSNDFKVGMKLEAVDRKNPQLICPATVGAVsNDQIYITFDGWrGAFDYWCRFdSRDIFPVGWCAKsGHPLQPPG 215 Octopus bimaculoides
ELT95891     143 PRDNFFEVGMKLEAVDRKNPHLICPATVGAVnKDQIHVTFDGWrGAFDYWCRYdSRDIFPMGWCAHsGHPLQPPG 217 Capitella teleta
XP_002586201 141 PKSNAFEVGMKLEAVDRKNPQLICPATIGAVdGKRIHVTFDGWlGAFDYWCDYdNRDIFPVGWCALsGHNLQPPG 215 Florida lancelet
XP_013401178 158 PSSNGFKVGMKLEAVDRKNPHLICPATIGAVnKDQVFITFDGWkGAFDYWCPYfSRDIFAVGWCSLsGHPLQPPG 232 Lingula anatina
EFX76808     275 PRYNMFRIGQKLEAVDRKNPHLICAATVGAVnNDSIFVTFDGWkGAFDYWCRYdSRDIFPVGFCAMvGHPLQPPG 349 common water flea
XP_002435493 160 PRTNEFRVGMKLEALDRKNPHLICPATVGAVkDDMIFVTFDGWrGAFDYWCRYdSRDIFPVGWCRRsGHPLQPPG 234 black-legged tick
XP_006817556 153 PKSNLFEVNMKLEAVDRKNPHLICPATVAAVrDNQIFVSFDGWrGAFDYWCDYdSRDIFACGTCSMaAIHLQAPG 227 Saccoglossus kowalev...
PIK50852     114 PEKNFFKVGMKLEAVDRKNSFLICPGTVAKVkDNMIFISFDGWsGAFDYWCEYnSRDIFPVGWCAKtGHYLQPPG 188 Japanese sea cucumber

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