4EDU,2BIV,1OI1


Conserved Protein Domain Family
MBT_SCML2_rpt2
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cd20109: MBT_SCML2_rpt2 
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second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins
SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439099
Aligned: 9 rows
Threshold Bit Score: 169.68
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyllysine
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Structure:4EDU; Homo sapiens SCML2 in a complex with histone H2A modified peptide through its second MBT repeat, contacts at 4A
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  # ## #               #  #   #                         ###  
4EDU_A       139 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTS 215 human
2BIV_A       167 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTS 243 human
1OI1_A       145 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTS 221 human
Q9UQR0       167 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTS 243 human
OCT92282     150 PLQNFFKTGMKLEAVDKKNPYLICPATIGDVKGDDVFITFDGWKGAFDYWCKYDSRDIFPIGWCSLTGDSLQPPGNS 226 African clawed frog
XP_005997901 167 PPHNLFKFGMKLEAVDKKNPYLICPATIGEVKGDEVFITFDGWRGAFDYWCKYDCRDIFPVGWCAMTGDTLQPPGNS 243 coelacanth
XP_007889868 168 PQDNSFKVGMKLEAVDRKNPHLICPATISEVKSDDVFITFDGWRGAFDYWCKYNSRDIFPVGWCGMTGDSLQPPGNR 244 elephant shark
XP_009916269 101 PVPNCFKVGMKLEAIDRKNPYLICPATIGDVKGDEVFVTFDGWRGAFDYWCRCDSRDIFPVGWCSLTGDALQPPGNN 177 white-tailed eagle
XP_025002357  32 PAANCFKVGMKLEAIDRKNPYLICPATIGDVKGDEVFVTFDGWRGAFDYWCRCDSRDIFPVGWCSLTGDALQPPGNN 108 chicken

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