2P0K


Conserved Protein Domain Family
MBT_SCMH1_rpt2
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cd20108: MBT_SCMH1_rpt2 
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second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins
SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439098
Aligned: 7 rows
Threshold Bit Score: 175.516
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyllysine
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on structure evidence that Homo sapiens SCML2 binds histone H2A modified peptide through its second MBT repeat.
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  # ## #               #  #   #                         ###
2P0K_A       136 PSHNFFKMGMKLEAVDRKNPHFICPATIGEVrGSEVLVTFDGWrGAFDYWCRFdSRDIFPVGWCSLtGDNLQPPG 210 human
OXB61874     226 PSQNFFKTGMKLEAVDRKNPHFICPATIGEVrGSEVLITFDGWrGAFDYWCRYdSRDIFPVGWCSLtGDNLQPPG 300 scaled quail
XP_014342231 172 PSQNHFKLGMKLEAVDRKNPHFICPATIGEVrGSEILVTFDGWrGAFDYWCRYdSRDIFPVGWCSLtGDNLQPPG 246 coelacanth
XP_007892947 171 PTQNHYKTGVKLEAVDRKNPHFICPATIGEVrGTEVLVTFDGWrGAFDYWCRYdSRDIFPVGWCALtGDNLQPPG 245 elephant shark
Q96GD3       162 PSHNFFKMGMKLEAVDRKNPHFICPATIGEVrGSEVLVTFDGWrGAFDYWCRFdSRDIFPVGWCSLtGDNLQPPG 236 human
NP_001083196 165 PPQNYFEIGMKLEAVDRKNPHFICPATIGEVrGSEILVTFDGWrGAFDYWCRYdSRDIFPVGWCSLtGDNLQPPG 239 African clawed frog
XP_011615135 171 PERNYFKVGMKLEAVDRKNPHFICPATVGALrGAEVLVTFDGWqGAFDYYCRFdSRDIFPVGWCHLtGDNLQPPG 245 torafugu

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