2R57


Conserved Protein Domain Family
MBT_dScm_rpt1
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cd20107: MBT_dScm_rpt1 
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first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins
Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.
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Statistics
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PSSM-Id: 439097
Aligned: 5 rows
Threshold Bit Score: 216.714
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2R57_A        26 QAQNPPNNDFKIGMKLEALDPRNVTSTCIATVVGVLGSRLRLRLDGSDsQNDFWRLVD-STEIHAIGHCEKNGGMLQPPL 104 fruit fly
XP_011665804 151 YLQPPGKTGFGLWMKLEALDPRNVTSTCIATVVGLIGPRLRLRLDGSDnKNDFWRLVD-SSDIRPIGHCEKNGGMLQPPL 229 purple sea urchin
ROT81200     190 QHKIPPKNEFKIGMKLEALDPRNLTSTCIATVVGTLGPRLRLRLDGSDnKNDFWRLVDcNNEIHPIGHCEEHGGMLQPPL 269 Pacific white s...
Q9VHA0       196 QAQNPPNNDFKIGMKLEALDPRNVTSTCIATVVGVLGSRLRLRLDGSDsQNDFWRLVD-STEIHAIGHCEKNGGMLQPPL 274 fruit fly
XP_002435493  47 QNTEPPTNEFRAGMKLEALDPRNVTSTCIATVVGVQGPRLRLRLDGGDnKNDFWRLVD-SGEVRPIGHCERSGGMLQPPL 125 black-legged tick

2R57_A       105 GFCMNASSWPGYLCKILNNA 124 fruit fly
XP_011665804 230 GFRMNASSWPMFLLRTLNNA 249 purple sea urchin
ROT81200     270 GFRMNASSWPMFLLKTLQNA 289 Pacific white shrimp
Q9VHA0       275 GFRMNASSWPGYLCKILNNA 294 fruit fly
XP_002435493 126 GFRMNASSWPMFLLKTLNKA 145 black-legged tick
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