4C5I,3F70,3H6Z


Conserved Protein Domain Family
MBT_dSfmbt-like_rpt4
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cd20100: MBT_dSfmbt-like_rpt4 
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fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family
The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439090
Aligned: 20 rows
Threshold Bit Score: 127.405
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyllysine
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
  • Structure:3H6Z; Drosophila Melanogaster Sfmbt in complex with peptide Rhr(Me)kVlr through its fourth MBT repeat; contacts at 4A
  • Structure:3F70; Homo sapiens L3MBTL2 binds N-methyl-lysine through its fourth MBT repeat; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #  #  # #               #  #   #                           
4C5I_A        364 HGFRVGMKLEAVDLMEprLICVATVTRIiHRLLRIHFDGWeeEYDQWVDCeSPDLYPVGWCQLtGYQLQPP 434  human
3H6Z_A        375 HGFEVGMSLECADLMDprLVCVATVARVvGRLLKVHFDGWtdEYDQWLDCeSADIYPVGWCVLvNHKLEGP 445  fruit fly
CBY10958      282 NPFKVGWKLEAVDLMDpkLICPSTVKNVcAGLLQIGFDGWgdDFDQFIPWrSPDIYPAGWCELvNHSLQAP 352  Oikopleura dioica
B2D6M2        537 DKFKVGLRLEAADMCEnqFICPATVKSVhGRLINVNFDGWdeEFDELYDVdSHDILPIGWCEAhSYVLQPP 607  Caenorhabditis elegans
XP_013413115  560 HGYRVGMKLEAVDLMEprLICVASVTQIvGRLLRIHFDGWekEYDQWIDCqSPDIYPVGWCEMvGYHLEGP 630  Lingula anatina
OTF74096     1462 QSFEEGMLLEAVDMLEpnLICLAVIKRRcGRLLLLHFIGWadNFDQWCDCcSPNIFPVGYCDLvEYPLQGP 1532 Euroglyphus maynei
PIK38516      578 RGFRPGQKIEAVDLIEpgLICVASIVKTaGSLISVHFDGWesSFDQWTDCsSSNVYPVGWCEMvGYPLQAP 648  Japanese sea cucumber
RMX37647      714 NNFKIGTKLEAVDLREpaLICPATVTDLkGPLLRIHFDGWdeSYDQLVDKdSLDIFPVSYCTSvDHPLQPP 784  Pocillopora damicornis
XP_029839303  480 HGFQEGMHAEAVDLMEprLICVGRITRVvGRLLRVHFDGWedSYDQWCDCeSPDLFPVGWCQLvDYPLEPP 550  
XP_030836926  610 RGFKVGHKLEAVDLIEsgFICVATVTKVaGPLLRVHFDGWdrSFDQWMDCdSPDICPVGWCEMvSYKLQPP 680

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