first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family
The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.
Feature 1:Pho/YY1 spacer binding site [polypeptide binding site]
Evidence:
Comment:Pho/YY1 transcriptional regulators contain an N-terminal highly conserved spacer region (also known as the REPO domain), a novel interacting motif that tightly binds to dSfmbt family proteins
Structure:4C5E: Drosophila melanogaster Sfmbt binds transcriptional regulator Pho spacer region through its first MBT repeat; contacts at 4A
Structure:4C5I; Homo sapiens MBTD1 binds transcriptional repressor protein YY1 spacer region through its first MBT repeat; contacts at 4A
Jiyao W et al.(2023). "The conserved domain database in 2023.",