4BXO,2M9M,4M6W


Conserved Protein Domain Family
XPF_nuclease_FAAP24

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cd20076: XPF_nuclease_FAAP24 
XPF-like nuclease domain of Fanconi anemia associated protein 24 kDa (FAAP24)
FAAP24, also called Fanconi anemia core complex-associated protein 24, plays a role in DNA repair through recruitment of the Fanconi anemia (FA) core complex to damaged DNA. It regulates FANCD2 monoubiquitination upon DNA damage and induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. FAAP24 may possess a high affinity toward single-stranded DNA (ssDNA). The nuclease domain of FAAP24 lacks the catalytic motif. The FANCM/FAAP24 complex is related to XPF/MUS81 endonucleases but lacks endonucleolytic activity. It binds branched DNA structures containing ssDNA regions, such as splayed-arm and 3'-flap DNA structures, and anchors the FA core complex to chromatin in repairing DNA interstrand crosslinks.
Statistics
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PSSM-Id: 410852
Aligned: 32 rows
Threshold Bit Score: 140.802
Created: 14-Nov-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
4BXO_B        20 GHIVANEKWRgSQLAEEMQGk-----------------IKLIFEDGLt-pDFYLSnRCCILYVTEADLVAGNGYRKRLVR 81  human
XP_002162852  22 GHVVLNSKYYnSLVSKSLTGf----------------gLKLLFDDTLgliDCYPSnSCAVIIAHEADLVAESELQVKVQK 85  Hydra vulgaris
XP_013787783  47 GHIIISYKWRgTELAKALEKg-----------------VKVIISEQLgvvDFHPSsDVAVAYVSEVDIIAGTSFRRKLVK 109 Atlantic horses...
KZS07993      36 GHILASLKWRnTSVVQKMTEs-----------------IKVLFSSDLgivDFHPSgDCAVIYISAAEMIEGLLYRKRLAG 98  Daphnia magna
XP_023713389  18 GCILVNEKWRgSKFEKDLSAi-----------------GRGIYCDNLgiiDFYLSqLCPVVYINESELISGVSFERKLKK 80  Cryptotermes se...
PRD36636      13 GHIYVNDKWKnSELFTFLNRmsfilllfslkyfccisrVQTIMIDSMdfiDFYPStEFAVIFVTEADLVAGINYRRNLAK 92  Nephila clavipes
PSN42738      17 GYILVNEKWKeSTFEKCLSGv-----------------GKAIYCDNLgaiDFYPSdHCPIIYINEGELLSGITYERKLEK 79  German cockroach
XP_025115421  22 GHIIVSGRWRsTELVADLQKs-----------------IQVHYEDSLgvvDFHPSsSIGVIYVSEADAVCGTGYRQKCVK 84  Pomacea canalic...
RDD43057      37 GHLIISDKYNdSRSIIQLLKe----------------qIKVVIESNLgliDFYPSpGCGVIHFKENDIIDTTGWKEKLRK 100 Trichoplax sp. H2
XP_026293728  18 GRILVNKRWRgSLLCKELDSa----------------dSKVAYSDGLgfvDFFPSdSCAVIYITEAELLTPKSFTERINL 81  western flower ...
Feature 1                                ##  ##  ##    ####     #   #  ## ##   
4BXO_B        82 VRNsn--nLKGIVVVEKtrmsEQYFPALQKFTVLDlGMVLLPVAsQMEASCLVIQLVQEQTK 141 human
XP_002162852  86 LSKf---aDKKVILAESteisDQYFKRLQLKMLGS-VVQVIPFTcVQDIGILIHQLGNSESK 143 Hydra vulgaris
XP_013787783 110 MRQad--cMRGVVIVEKtpytTQQFYSLQKFTVLElGLTLIPIAnSSEAGQLLIQMVHAENR 169 Atlantic horseshoe crab
KZS07993      99 LKAvk--gIRKVIVAERtylsLQQFSSLQQFAVLElELDLIPVT-ENGLHSLLVQMVSAENK 157 Daphnia magna
XP_023713389  81 ILEtg--qHHGVVIADRnnltIKQFSELQNHCFTS-KITLIPVGnVSELPQLLVQMAYVECK 139 Cryptotermes secundus
PRD36636      93 LKKaganyEKNAVIVEKtsisNQYFGSFQKFAVIElGLGIVPVSgPDECCQALVAMVRMGSE 154 Nephila clavipes
PSN42738      80 MRKvs--nTGGIIIADRnnftIKHFSDLQDKCFAM-DLILIPIGnVSELPQILTQMVVCNIY 138 German cockroach
XP_025115421  85 LHMan--rIRGIVIVERtpasDQYFKDVQIFCGLEiGLSVVPVSgPIEAAGFLKQLVHAEGK 144 Pomacea canaliculata
RDD43057     101 LMQs---pLKVIILAEKtltnNQYYDQLQTSAVIEfGMVLLPIHsTNDIASYLSSLVNQATR 159 Trichoplax sp. H2
XP_026293728  82 LAKey--hNRGVVIVDVc--rSTSYQDFQDLACIElELTVYPVSqQNEIPRILRALTYAETR 139 western flower thrips

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