4P0P,2ZIW,2ZIU,2ZIX


Conserved Protein Domain Family
XPF_nuclease_Mus81
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cd20074: XPF_nuclease_Mus81 
XPF-like nuclease domain of Mus81
Mus81 is a crossover junction endonuclease that interacts with Eme1 and Eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. The typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. Mus81 may be required in mitosis for the processing of stalled or collapsed replication forks. Mus81 consists of the active nuclease domain with the GDX(n)ERKX(3)D motif which is required for metal-dependent endonuclease activity and two helix-hairpin-helix (HhH2) domains.
Links
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Statistics
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PSSM-Id: 410850
Aligned: 252 rows
Threshold Bit Score: 97.1681
Created: 14-Nov-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 6 residue positions
Conserved feature residue pattern:G D E R K DClick to see conserved feature residue pattern help
Evidence:
  • Comment:consensus: GDX(n)ERKX(3)D used to define active member of this family
  • Structure:4P0P; Homo sapiens Mus81 contains an active site, GDX(n)ERKX(3)D.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                        ##                               
4P0P_A         21 EYRVLLCVDIGEtrgg-----ghrpELLRELQRLhVTHTVRKLh--vGDFVWVaqetnpr------dpanpgELVLDHIV 87   human
XP_019626309  245 SDGIVLLVDVREwggdr----vklgELHRYLCRLgVRHRTASLq--cGDYSWVwkc-------------ageEHVLPVLV 305  Belcher's lan...
XP_004989214  306 RPAVVLLVDSREgggry----hllkEMCAALDRTgVTFRTEALa--lGDYGWKyrgq------------dggESMLPVLV 367  Salpingoeca r...
XP_013403533  221 SDGLVILVDTQEfggdh----rglgQLIDLIKQTgLRYRTKKLa--cGDYSWLlrc-------------ggeERVMPLLV 281  Lingula anatina
XP_021363949  206 RDGVILQVDHREhggdr----lglgQLCDLLAGEgVTYRTRQLr--tGDYQWVwrc-------------egqERDLPCIA 266  Yesso scallop
OEU11642      593 YEGICLAVDLREggagqagsrkvlhEMCNRLDMKkIPYITTTLt--iGDYCFFs-----------------gDLLCPILV 653  Fragilariopsi...
XP_005772945  164 AGVVLLLVDEREgggss---cgkmaELCDALDREgARFETRRLpsghGDYEWVladgs----------paahEVVLPLIV 230  Emiliania hux...
XP_009037082  203 PDDVVVLVDEREgggda----hhlpTIATFLKDEgVAYETRRLptgfGDYAVArrradl--------agdrvDGVYPMLL 270  Aureococcus a...
RMX55689      439 NRQVCLLVDSEEpl---------reRFVRVVQQRgMSAKTRKLp--vGDFLWVllppgvnpd--tvrdmpdqELVLPMVV 505  Pocillopora d...
XP_013414553  505 GHQVVLLMDSQEkq---------qdRLVALARQHqIPVQVRELk--cGDYIWIvvpewacdglkyievlpdqEKVLPHIV 573  Lingula anatina

Feature 1         ###   #                                                                         
4P0P_A         88 ERKRlDDLCSSIIDGRFREQKFRLKRcg--------lERRVYLVEEhgsvhn---------------------lslpeST 138  human
XP_019626309  306 ERKRaDDLAWSLKDGRYFTQKEKMLEfrrrfspyslhCSLKYVLECtpeqymvrcadg--------crgvarcgnptvEQ 377  Belcher's lan...
XP_004989214  368 ERKRlDDLSDSLVDGRFVSQCTRMMQsrda----fpsTQLHYIVEGtysgfrvgtcca--------rgciskhgqateSE 435  Salpingoeca r...
XP_013403533  282 ERKRaDDLAKSLVDGRYGKQRRDMVKwkaaftsqgvpAVLKYILESrpeqfvvqcadg--------cggvgkcgypsaLQ 353  Lingula anatina
XP_021363949  267 ERKRvDDMARTLKEGRFWTQVTKMKAfkaefeergvaCIVHYLVEGnpenyvvrcgdg--------cqgvgrcgypslQQ 338  Yesso scallop
OEU11642      654 ERKSvQDVAQSIHDGRWESQKRRMYHgqfvf--gydnCRIAFIIEGkvekqlvsngy-----------igsakfkvpkER 720  Fragilariopsi...
XP_005772945  231 ERKGcLDVSASMRDGRWRRQQAAMEArnase--fggaATIEYLLEGdvsktkhtcaacaalpggggvggcptdgwptvAA 308  Emiliania hux...
XP_009037082  271 ERKSaVDVADSLRDGRWAKQHDAMRRtadr---fpggAALVYVVEGdparhvhtacgcg-------clgvgscgnpnlAA 340  Aureococcus a...
RMX55689      506 ERKTwDDLWSSLKSTRFLNQVNRMKKcg--------lANLFYLVEGsprelkg------------------npgpevaSF 559  Pocillopora d...
XP_013414553  574 ERKTwDDLLNSTQTTRFRNQVESMKRsg--------lRDKFYLIEGamhgmrs------------------kpsiyqqQD 627  Lingula anatina

Feature 1                                             
4P0P_A        139 LLQAVTNTQVidGFFVKRTAdIKESAAYLALLTRGL 174  human
XP_019626309  378 LNNVLEELDDsdEFDLVRTEnIEGTVEFLATVTVEL 413  Belcher's lancelet
XP_004989214  436 IEAKLQELRDe-KFTVHRTTsFLETVHVLATLHTQL 470  Salpingoeca rosetta
XP_013403533  354 LNKAIEDLENcqDFEVLKTDnIGHTVEMLAIITAEL 389  Lingula anatina
XP_021363949  339 VKCAFRDLSGdkDLVAQATDdLQATVAVIASITTDL 374  Yesso scallop
OEU11642      721 FDEEIANLKSe-GFDVIRTPhRDHSMFALARWAEAC 755  Fragilariopsis cylindrus CCMP1102
XP_005772945  309 VEEELRRAEA--TYKVTRTAsIAHTAAHLAAEQRRL 342  Emiliania huxleyi CCMP1516
XP_009037082  341 VAAAVDARERs-GVEIARTRdVRATARLVAERYRAA 375  Aureococcus anophagefferens
RMX55689      560 LQDKLDSLLLeeQFLVNHGSpKLKTYSEFSRGRKLR 595  Pocillopora damicornis
XP_013414553  628 LQVKLSSLLMeeGFLVNYTStWLKTAQWLFWLTNMV 663  Lingula anatina

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