Conserved Protein Domain Family
FH_FOXP4
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cd20067: FH_FOXP4 
Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins
FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is not required for T cell development, but is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410841
Aligned: 6 rows
Threshold Bit Score: 185.711
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens FOXP3 (3QRF) binds DNA through its Forkhead domain.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ##                 ##  #             # #  #  ##  #      #      # #          
Q8IVH2       467 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDErEYQKR 546 human
Q4VYR7       436 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDElEYQKR 515 African clawed ...
XP_014347677 357 RPPFTYASLIRQAILEAPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDElEYQKR 436 coelacanth
XP_007897787 515 RPPFTYASLIRQAILETSDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDElEYQKR 594 elephant shark
NP_001186420 482 RPPFTYASLIRHAILEAPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEvEYQKR 561 zebrafish
XP_013794978 357 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKXXXRHNLSLHKCFVRVENVKGAVWTVDEhEYQKR 436 Apteryx austral...

Feature 1               
Q8IVH2       547 RPPKMTG 553 human
Q4VYR7       516 RPPKMTG 522 African clawed frog
XP_014347677 437 RPPKMTG 443 coelacanth
XP_007897787 595 RPPKMTG 601 elephant shark
NP_001186420 562 RPPKMTG 568 zebrafish
XP_013794978 437 RPPKMTG 443 Apteryx australis mantelli

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