3QRF


Conserved Protein Domain Family
FH_FOXP3
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cd20066: FH_FOXP3 
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Forkhead (FH) domain found in Forkhead box protein P3 (FOXP3) and similar proteins
FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg), which are required for maintaining self-tolerance. It may also have intrinsic regulatory function in conventional T (Tconv) cells. A deletion of the Forkhead domain arising from a frame-shift mutation in mouse FOXP3 is linked to the autoimmune disorder scurfy, and a similar congenital disease in humans is known as IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410840
Aligned: 6 rows
Threshold Bit Score: 153.962
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingdimer interface
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:3QRF; Homo sapiens FOXP3 bridges two molecules of DNA by forming a domain-swapped dimer, contacts at 4A.
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ##                 ##  #             # #  #  ##  #      #      # #          
3QRF_F         2 RPPFTYATLIRWAILEAPeKQRTLNEIYHWFTRMFAFFRnHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKK 81  human
Q9BZS1       337 RPPFTYATLIRWAILEAPeKQRTLNEIYHWFTRMFAFFRnHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKK 416 human
ACQ44666     309 RPPFTYASMIRWAILKSPeKQLTLKEIYQWFTSMFFYFRhNTATWKNAVRHNLSLHKCFVRVEGRKGSVWTVDEEEFLRR 388 zebrafish
NP_001121199 371 RPPFTYASLIRWAILESPqKQLALNEIYHWFTRMFAFFRyNTATWKNAVRHNLSLHKCFVRVENIKGAVWMVDELEFQRK 450 African clawed ...
XP_007884187  76 RPPFTYAALIRWAILETSeKQMTLNEIYLWFTRKFAFFRnNTATWKNAVRHNLSLHKCFVRVENMRGAVWTVDEMEFQRR 155 elephant shark
KYO48397      48 RPPFTYAALIRWAIMESPeRQLTLNEIYHWFSRSFGYFRhNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEGEFQRR 127 American alligator

Feature 1         
3QRF_F        82 R 82  human
Q9BZS1       417 R 417 human
ACQ44666     389 K 389 zebrafish
NP_001121199 451 R 451 African clawed frog
XP_007884187 156 K 156 elephant shark
KYO48397     128 R 128 American alligator

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