Conserved Protein Domain Family
FH_FOXO6
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cd20063: FH_FOXO6 
Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins
FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis and prognosis. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.
Links
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Statistics
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PSSM-Id: 410837
Aligned: 6 rows
Threshold Bit Score: 195.27
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ##                 #   #                       ## ##  #      #        ## #   
A8MYZ6        89 GNLSYADLITKAIESApdkRLTLSQIYDWMVRYVPYFKDKgdsnssaGWKNSIRHNLSLHtRFIRVQNEgtGKSSWWMLN 168 human
XP_005993189  93 GNLSYADLITKAIESSpdkRLTLSQIYDWMVRYVPYFKDKgdsnssaGWKNSIRHNLSLHtRFIRVQNEgaGKSSWWMLN 172 coelacanth
XP_007893171 130 GNLSYADLITKAIESSsdhRLTLSQIYDWMVRYIPYFKDKgdsnssaGWKNSIRHNLSLHsRFIRVQNEgtGKSSWWMLN 209 elephant shark
NP_001152754  55 GNMSYADFITKAIESSperRLTLSQIYDWMVRFVPYFKDKgdsnssaGWKNSIRHNLSLHtRFIRVQNEgtGKSSWWMLN 134 African clawed ...
KFO79777      90 GNLSYADLITKAIESSpekRLTLSQIYDWMVRYVPYFKDKgdsnssaGWKNSIRHNLSLHtRFIRVQNEgtGKSSWWMLN 169 common cuckoo
NP_001128604 104 GNQSYADLITRAIESTpekRLTLSQIYDWMVRFVPYFKDKgdsnssaGWKNSIRHNLSLHtRFIRVQNEgtGKSSWWMLN 183 zebrafish

Feature 1                
A8MYZ6       169 PEGGKTGK 176 human
XP_005993189 173 PEGGKTGK 180 coelacanth
XP_007893171 210 PDGGKTGK 217 elephant shark
NP_001152754 135 PEGGKTGK 142 African clawed frog
KFO79777     170 PEGGKTGK 177 common cuckoo
NP_001128604 184 PEGGKMGK 191 zebrafish

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