Conserved Protein Domain Family
FH_FOXJ3
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cd20052: FH_FOXJ3 
Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins
FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. Polymorphisms in the FOXJ3 gene may be associated with the development of rheumatoid arthritis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410826
Aligned: 11 rows
Threshold Bit Score: 166.742
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                 ##  #                  ## ##  #      #         ### #   
Q9UPW0        77 GKPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYREAGSGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAID 155 human
XP_014342709  62 GKPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYREAGSGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAID 140 coelacanth
XP_007908908  61 GKPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYREAGSGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAID 139 elephant shark
NP_001313317  61 GKPPYSYASLITFAINSSPKKKMTLSEIYQWICDNFPYYREAGSGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAID 139 zebrafish
ADB22670      64 GKPPYSYANLITFAINSSPKKKMTLSEIYQWICENFPFYREAGNGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAID 142 Saccoglossus kow...
PVD35308      17 GKPPYSYANLITFAINSSPQKKLTLSEIYQWICDNFPYYRDAGNGWKNSIRHNLSLSKCFLKVPRSKDDPGKGSYWIID 95  Pomacea canalicu...
PFX29934     392 SKPPYSYANLITFAINSSPKKKMTLSEIYQWICDKFPYYKEAGNGWKNSIRHNLSLNKCFMKVPRSKDDPGKGSYWAID 470 Stylophora pisti...
NP_001073017  62 GKPPYSYANLITFAINSSPKKKMTLSEIYQWICENFPYYREAGNGWKNSIRHNLSLNKCFMKVPRSKDDPGKGSYWAID 140 purple sea urchin
XP_013416330  74 GKPPYSYANLITFAINSSNKKKMTLSEIYQWICDNFPYYREAGNGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAID 152 Lingula anatina
OCT72721      62 GKPPYSYASLITFAINSSPKRKMTLSEIYQWICDNFPYYKEAGSGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAID 140 African clawed frog
XP_002591636   3 GKPPYSYANLITFAINSSPKKKMTLSEIYQWICDNFPYYRDAGNGWKNSIRHNLSLNKCFLKVPRSKDDPGKVSSFLKS 81  Florida lancelet

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