1D5V


Conserved Protein Domain Family
FH_FOXC2
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cd20045: FH_FOXC2 
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Forkhead (FH) domain found in Forkhead box protein C2 (FOXC2) and similar proteins
FOXC2, also called Forkhead-related protein FKHL14, Mesenchyme fork head protein 1 (MFH-1 protein), or transcription factor FKH-14, acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410819
Aligned: 8 rows
Threshold Bit Score: 187.597
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative DNA
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                 ##  #                  ## ##  #      #         ### #   
1D5V_A         2 LVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLD 81  human
Q99958        70 LVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLD 149 human
NP_990469     70 LVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLD 149 chicken
Q6NVT7        70 LVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLD 149 tropical clawed...
XP_005995944  70 LVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLD 149 coelacanth
XP_007887427  83 LVKPPYSYIALITMAIQNTPDKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWSLD 162 elephant shark
CAL47033      68 LVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWCLD 147 bowfin
KFM66507      80 MVKPPYSYIALITMAIQNSPEKKITLNGIYQFIIDRFPFYRENKQGWQNSIRHNLSLNDCFVKVPRDDKKPGKGSYWTLD 159 Stegodyphus mim...

Feature 1                  
1D5V_A        82 PDSYNMFENG 91  human
Q99958       150 PDSYNMFENG 159 human
NP_990469    150 PDSYNMFENG 159 chicken
Q6NVT7       150 PDSYNMFENG 159 tropical clawed frog
XP_005995944 150 PDSYNMFENG 159 coelacanth
XP_007887427 163 PDSYNMFENG 172 elephant shark
CAL47033     148 PDSYNMFDNG 157 bowfin
KFM66507     160 PDSANMFDNG 169 Stegodyphus mimosarum

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