2KIU,3QRF,2A07


Conserved Protein Domain Family
FH_FOXP

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cd20033: FH_FOXP 
Click on image for an interactive view with Cn3D
Forkhead (FH) domain found in the Forkhead box protein P (FOXP) subfamily
The FOXP subfamily includes four winged helix transcription factors, FOXP1-4. They are involved in the development of the central nervous system. Mutations in FOXP1, also called Mac-1-regulated Forkhead (MFH), leads to developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. FOXP2, also called CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal and cardiovascular tissues. FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Statistics
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PSSM-Id: 410807
Aligned: 17 rows
Threshold Bit Score: 126.012
Created: 17-Dec-2018
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:3QRF; Homo sapiens FOXP3 bridges two molecules of DNA by forming a domain-swapped dimer, contacts at 4A.
    View structure with Cn3D
  • Structure:2A07; Homo sapiens FOXP2 binds DNA through its Forkhead domain, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ##                 ##  #                 #  #  ##  #      #        # #   
2KIU_A         4 RPPFTYASLIRQAILESpekqLTLNEIYNWFTRMFPYFRrn--aaTWKNAVRHNLSLHkYFVRVEn--VKGAVWTVD 76  human
3QRF_F         2 RPPFTYATLIRWAILEApekqRTLNEIYHWFTRMFAFFRnh--paTWKNAIRHNLSLHkCFVRVEs--EKGAVWTVD 74  human
XP_012566250 399 RPPYTYASLIRQGVMDSpngeLTLNEIYNWFMKNFAYFRkn--tsTWKNAVRHNLSLHkCFVRKEn--FKGAVWTVD 471 Hydra vulgaris
CAE51211     462 RPPFTYASLIRQAILESsdqcLTLCEIYAWFMKNFVYFRdn--npTWKNAIRHNLSLHkCFVRVElnkSRGAVWTVD 536 Suberites domuncula
RDD46010     483 RPPFTYASMIRQAIIESphqqLSLSEIYNWFVAHFKYFRnkedaaTWKNAVRHNLSIQqCFVRVEt--LNGAVWTFN 557 Trichoplax sp. H2
VDM26650      89 RPRFTYASLIRQAICESpnkcLSLSEIYAWLQKEFLYFRqn--eaTWKNAIRHNLSLHkCFRRVEt--AGGSVWVFD 161 Hydatigera taeniae...
EFX63453     474 RPPFTYASLIRQAIIESperqLTLNEIYTWFQNTFCYFRhn--aaTWKNAVRHNLSLHkCFMRVEn--VKGAVWTVD 546 common water flea
ELT95700     317 RPPFTYASLIRQAIIESpdkqLTLNEVYQWFMNTFAFFRkn--qaTWKNAVRHNLSLHkCFMRVEd--VKGAVWTVD 389 Capitella teleta
PVD24512     350 RPPFTYASLIRQAIVESphrqLTLNEIYQWFQATFAYFRrn--eaTWKNAVRHNLSLHkCFMRVEn--VKGAVWTVD 422 Pomacea canaliculata
PRD35148      46 RPPFTYASLIRQAIIEApekqLTLNEIYNWFQNTFCYFRrn--aaTWKNAVRHNLSLHkCFMRVEn--VKGAVWTVD 118 Nephila clavipes

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