3CO7,1E17,2MBF,2UZK,3L2C


Conserved Protein Domain Family
FH_FOXO

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cd20032: FH_FOXO 
Click on image for an interactive view with Cn3D
Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily
The FOXO subfamily includes several winged helix transcription factors: FOXO1, FOXO3, FOXO4 and FOXO6. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members. FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis, and prognosis. The FH domain is a winged helix DNA-binding domain.
Statistics
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PSSM-Id: 410806
Aligned: 38 rows
Threshold Bit Score: 106.223
Created: 17-Dec-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:3CO7; Homo sapiens FOXO1 binds DNA through its Forkhead domain, contacts at 4A.
  • Structure:2UZK; Homo sapiens FOXO3 binds DNA through its Forkhead domain, contacts at 4A.
  • Structure:3L2C; Homo sapiens FOXO4 binds DNA through its Forkhead domain, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ##                 #   #                         ## ##  #       #            
3CO7_C         12 GNLSYADLITKAIESSaekRLTLSQIYEWMVKSVPYFKDKgdsn--ssaGWKNSIRHNLSLHs-KFIRVQNeg------- 81   human
XP_001627679  177 SGLTYSELLAKAISSSpeqRLTLQGIYRWFEENVEGISNGsis----nhDWKNTVRHTLSMRk-RFVRVAMts------- 244  starlet sea a...
CBY38985      100 IPMTYYELIETALINSengKLTLKEIYDWLVKNVAEFHEGns------kKWQNSIRHNLSLHrsRFKRELNse------- 166  Oikopleura di...
CBY20943      134 RRMTYAELIVEAIKSSkenRMTLRQIYQWMSRNIREFGPHggpgcpstnSWKNSIRHNLSLHe-MFKRVPNht------- 205  Oikopleura di...
CBY18613      148 VHHTYQELIVIAITQSsnrCLTLAGIYQWMLENVREFQPNsttg-pamnSWKNSIRHNLSLHk-CFQKRTNsq------- 218  Oikopleura di...
ELA37524      253 TNEPYAQLIWKALKSQpdrCMTLQQLYQWFLKNTDKPEKAgg------dGWHNSIRHNLSMNf-AFERMEElpthei--- 322  Colletotrichu...
KHN94658      236 ADEPYAKLIYKAIMTRpdySMTLQEIYQWFREHTTKAVTEt-------gGWQNSIRHNLSMNa-AFRKRDKviskaprnv 307  Metarhizium a...
XP_015922447   33 GSKSYSELITEAIVSAknkRMTLSEIYEYIIRNVPYFHDKgdsk--sscGWKNSIRHNLSLHn-RFQRIQPddi------ 103  common house ...
OQD87225      204 GPTPYSHLIFRALKEAkdnKLPLQGIYNWFERNTDKAKSSgs------kGWQNSIRHNLSMNa-GFEAVKEelg------ 270  Penicillium a...
XP_020915640  117 GSSSYSDLITMAILSSpskKMTLQEIYEWIGNNIPYFGDKkdvr--ttaGWKNSVRHTLSIRk-KFIRLPNyel------ 187  Exaiptasia pa...
Feature 1                  ## #   
3CO7_C         82 ------tGKSSWWMLN 91   human
XP_001627679  245 ------kGNKSWWTVK 254  starlet sea anemone
CBY38985      167 ------eGKSSFWSLN 176  Oikopleura dioica
CBY20943      206 ------rGESAFWVID 215  Oikopleura dioica
CBY18613      219 ------pGESSLWVYV 228  Oikopleura dioica
ELA37524      323 -tgssseRIPSKWHLK 337  Colletotrichum fructicola Nara gc5
KHN94658      308 sgtteesKRVNEWVLE 323  Metarhizium album ARSEF 1941
XP_015922447  104 ----ettNRCSYWQMN 115  common house spider
OQD87225      271 ----pgkKAVNFWRLT 282  Penicillium antarcticum
XP_020915640  188 ----gniNYKSQWTIN 199  Exaiptasia pallida

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