Conserved Protein Domain Family
FH_FOXH
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cd20022: FH_FOXH 
Forkhead (FH) domain found in the Forkhead box protein H (FOXH) subfamily
The FOXH subfamily includes a winged helix transcription factor, FOXH1, which is also called Forkhead activin signal transducer 1 (Fast-1), or Forkhead activin signal transducer 2 (Fast-2). FOXH1 acts as a transcriptional activator that recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. It is required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. FOXH1 forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410796
Aligned: 13 rows
Threshold Bit Score: 129.792
Created: 17-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #                 ##  #                  ## ##  #      #           ### #   
O75593        33 KPPYTYLAMIALVIQAAPsRRLKLAQIIRQVQAVFPFFRedYEGWKDSIRHNLSSNrCFRKVPkdpa-kpqAKGNFWAVD 111 human
P70056       117 KPPYSYLAMIALVIQNSPeKRLKLSQILKEVSTLFPFFNgdYMGWKDSIRHNLSSSdCFKKILkdpg-kpqAKGNFWTVD 195 African clawed ...
Q8JIT7        69 KPPYSYLAMISLVIQNSPeKRLKLSQILQDISSLFPFFKgnYQGWKDSIRHNLSSNdCFRKVLkdpl-kpqAKGNYWTVD 147 African clawed ...
Q9I9E1        97 KPPYSYLAMIAMVIQNSPeKKLTLSEILKEISTLFPFFKgnYKGWRDSVRHNLSSYdCFVKVLkdpg-kpqGKGNFWTVE 175 zebrafish
XP_015269531  45 KPPYTYLAMIALVIQAAPdKRLRLAQIIKEISSLFPFFKegYQGWKDSIRHNLSSNdCFHKVLkdpa-kpkAKGNFWTVD 123 Gekko japonicus
XP_007910257 152 KPPYTYLALIAMAILNSPeKRLKLSQILHDISVMFPFFKghYKGWKDSVRHNLSLNnCFIKVLndpk-rpqAKGNYWTVD 230 elephant shark
NP_001071992  38 KPPYSYVGLIALAIQNSTtKMLKLSDILLRISTMFPFFKgeYQGWRDSVRHNLSQNkCFKKVLpdps-rphSKGNYWTVD 116 vase tunicate
ACE79158      88 KPPYSYLALVVMAIQNAPeKKLPLKEIHEALKKMYPFFRgdYTGWKDSVRHNLSTYkCFYKVPkdps-rpfAKGNYWAVY 166 Florida lancelet
BAQ19209      26 KPPYSYLGMVALIIQCSPgRQQSLAGIIDTLTDMFPFFQgeYKGWKDSVRHNMTNSdCFYKVEelvnnvkrMKRCKWAID 105 owl limpet
XP_014677554  40 KPPFSYLGLMVTAIQSSPsGKLTLSGIHRALENMFPFFKceYSGWKDSVRHNLSLNkCFVKVLkdes-rpnGKGNHWTVN 118 Priapulus caudatus
XP_025075954 102 KPPYAYLAMIIVAIHYSPnGHMTLAEVIKALENMFSFFRcsYKGWKDSVRHNISNSpCIVKVEpepg-agaFKAARWRVF 180 Pomacea canalic...
EKC39215     200 KPPYPYTGMIIHAINSTTeKSLTLTGIISKLKEMFTFFKgsYTGWRDSVRHNLSHNaCFVKGGrcs--kpeSNGNLWHVD 277 Pacific oyster
AAS21341     491 KPPYSYSSIVMIALLTEPsRALPLREIVRRISTLFPFFRgpYLGWKDSIRHNLSSCrSFVKRPnn-----sKGGSLWSFL 565 Oikopleura dioica

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