2HDC


Conserved Protein Domain Family
FH_FOXD

?
cd20018: FH_FOXD 
Click on image for an interactive view with Cn3D
Forkhead (FH) domain found in the Forkhead box protein D (FOXD) subfamily
The FOXD subfamily includes four winged helix transcription factors, FOXD1-4. FOXD1, also called Forkhead-related protein FKHL8 or Forkhead-related transcription factor 4 (FREAC-4), is involved in transcriptional activation of Placental Growth Factor (PGF) and the complement component (C3) genes. It plays an important role in early embryonic development and organogenesis, and functions as an oncogene in several cancers. FOXD2, also called Forkhead-related protein FKHL17 or Forkhead-related transcription factor 9 (FREAC-9), is a probable transcription factor involved in embryogenesis and somatogenesis. FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. FOXD4, also called Forkhead-related protein FKHL9 or Forkhead-related transcription factor 5 (FREAC-5), is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Statistics
?
PSSM-Id: 410792
Aligned: 15 rows
Threshold Bit Score: 158.497
Created: 17-Dec-2018
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2HDC; Rattus norvegicus FOXD3 binds DNA through its Forkhead domain, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1         ######                ##                 ## ### ###  #     ###### # ######   
2HDC_A         2 KPPYSYIALITMAILQSPqKKLTLSGICEFISNRFPYYRekfPAWQNSIRHNLSLNDCFVKIPREPGNpGKGNYWTLD 79  Norway rat
Q16676       125 KPPYSYIALITMAILQSPkKRLTLSEICEFISGRFPYYRekfPAWQNSIRHNLSLNDCFVKIPREPGNpGKGNYWTLD 202 human
ABB89476     112 KPPYSYIALITMSILQSPqKRLTLSGICEFIMNRFPYYRekfPVWQNSIRHNLSLNDCFVKIPREPGNpGKGNYWTPD 189 purple sea urchin
NP_001164677 136 KPPYSYIALITMAVLQSPqKRLTLSGICEFIMNRFPYYRerfPVWQNSIRHNLSLNDCFVKIPREPGNpGKGNYWTLD 213 Saccoglossus kowa...
Q12950       104 KPPSSYIALITMAILQSPhKRLTLSGICAFISDRFPYYRrkfPAWQNSIRHNLSLNDCFVKIPREPGRpGKGNYWSLD 181 human
ELT88034      19 KPPYSYIALITMAVLQSPqKRLTLSGICEFIMNRFPYYRerfPAWQNSIRHNLSLNDCFVKIPREPGNpGKGNYWTLD 96  Capitella teleta
AJV21309     124 KPPYSYIALITMSVLQSPrKRLTLSGICEFIMNRFPYYKerfPAWQNSIRHNLSLNDCFIKIPREPGNpGKGNYWTLD 201 Terebratalia tran...
PVD23064     307 KPPYSYIALITMSILQSPrKRLTLSGICEFIMNRFPYFRekfPAWQNSIRHNLSLNDCFVKIPREPGNpGKGNYWTLD 384 Pomacea canaliculata
AWV91603     112 KPPYSYIALITMSILQSPqKKLTLSQICEFIMNRFPYYRerfPVWQNSIRHNLSLNDCFVKIPREPGNpGKGNYWTLD 189 amphioxus
KPM07331      79 KPPFSYIALITMAILQSPhKKLTLNGICEFIRNRFPFYRekyPMWQNSIRHNLSLNDCFVKIPREPGNpGKGNYWTLD 156 Sarcoptes scabiei

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap