1D5V


Conserved Protein Domain Family
FH_FOXC
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cd20017: FH_FOXC 
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Forkhead (FH) domain found in the Forkhead box protein C (FOXC) subfamily
The FOXC subfamily includes two winged helix transcription factors, FOXC1 (also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3) and FOXC2 (also called Forkhead-related protein FKHL14, or Mesenchyme fork head protein 1). FOXC1 is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. FOXC2 acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410791
Aligned: 13 rows
Threshold Bit Score: 167.432
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative DNA
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #                  ##  #                  ## ##  #      #         ### #  
1D5V_A         4 KPPYSYIALITMAIQNApe-kKITLNGIYQFIMDRFPFYRenkQGWQNSIRHNLSLNeCFVKVPRDDKKpGKGSYWTL 80  human
Q12948        78 KPPYSYIALITMAIQNApd-kKITLNGIYQFIMDRFPFYRdnkQGWQNSIRHNLSLNeCFVKVPRDDKKpGKGSYWTL 154 human
P32027        70 KPPYSYIALIAMAIQNAad-kKVTLNGIYQYIMERFPYYRdnkQGWQNSIRHNLSLNeCFVKVARDDKKpGKGSYWTL 146 fruit fly
AMY99571      88 KPPYSYIALIAMAIQSApd-kKVTLNGIYQFIMDRFPFYRenkQGWQNSIRHNLSLNeCFIKVPRDDKKpGKGSYWSL 164 Novocrania anomala
EFX88578      15 KPPYSYIALIAMAIQSAapekKITLNGIYQFIMDRFPYYRenkQGWQNSIRHNLSLNeCFVKVPRDDKKpGKGSYWTL 92  common water flea
CAH69694      48 KPPYSYIALIAMAIQNApd-kKVTLNGIYQFIMDRFPYYRenkQGWQNSIRHNLSLNeCFIKVPRDDKKpGKGSYWSL 124 Florida lancelet
NP_001158465  70 KPPYSYIALIAMAIQNApe-kKVTLNGIYQFIMDRFPFYRenkQGWQNSIRHNLSLNdCFIKVPRDDKKpGKGSYWSL 146 Saccoglossus kowa...
ABB89478      93 KPPYSYIALIAMAIMNAsd-kKITLNGIYQFIMDRFPFYRenkQGWQNSIRHNLSLNdCFIKIPRDDKKpGKGSYWSL 169 purple sea urchin
NP_001071708  99 KPPYSYIALIAMAIQNApd-kKVTLNGIYQWIMERFPFYRenkQGWQNSIRHNLSLNeCFVKIPRDDKKpGKGSYWTM 175 vase tunicate
OQR73677     128 KPPYSYIALIAMAIQNAde-kRITLNGIYQFIMERFPFYRenkQGWQNSIRHNLSLNeCFVKIVRDDKKpGKGSYWTL 204 Tropilaelaps merc...
ADC35031       9 KPPYSYIALIAMSIMSQpd-kKITLNGIYQFIMDRFPYYRenkQGWQNSIRHNLSLSeCFVKIPRDDKKpGKGSYWTL 85  Capitella teleta
CBI70344      31 KPPYSYIALIAMAIQSSpe-kRVTLNGIYAFIMDRFPFYRenkQGWQNSIRHNLSLNeCFMKIPRDDKKpGKGSYWTL 107 common limpet
AFK74873      89 KPPYSYIALISMAIQSSpd-kKLTLSGIYQFIMERFPYYRqnkQGWQNSIRHNLSLNeCFLKVPRDDNKpGKGSYWSL 165 Hydra vulgaris

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