Conserved Protein Domain Family
FH_FOXB
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cd20016: FH_FOXB 
Forkhead (FH) domain found in the Forkhead box protein B (FOXB) subfamily
The FOXB subfamily includes two winged helix transcription factors, FOXB1 (also called transcription factor FKH-5) and FOXB2 (also called transcription factor FKH-4). FOXB1 controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. FOXB2 may act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410790
Aligned: 15 rows
Threshold Bit Score: 166.145
Created: 17-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #                 ##  #                  ## ##  #      #         ### #    
Q5VYV0        13 KPPYSYISLTAMAIQHSaekMLPLSDIYKFIMERFPYYRehtqRWQNSLRHNLSFNdCFIKIPrrpdqpGKGSFWALHP 91  human
P34683        13 KPPYSYIWLTYMAIQDSddkMLPLTEIYKYIMDRFPFYRkntqRWQNSLRHNLSFNdCFIKIPrradrpGKGSYWAVHP 91  Caenorhabditis e...
P32028        13 KPPYSYISLTAMAIWSSpekMLPLSDIYKFITDRFPYYRkntqRWQNSLRHNLSFNdCFIKVPrrpdrpGKGAYWALHP 91  fruit fly
OQR77359     169 KPPYSYISLTFMAIQSSkekMLTLNEIYKFIMDRFPYYRkntqRWQNSLRHNLSFNdCFIKIPrrpdrpGKGSYWALHP 247 Tropilaelaps mer...
XP_013397763  13 KPPYSYIALTAMAIQSSaekMLPLSDIYKFIMDKFPFYRentqRWQNSLRHNLSFNdCFIKIPrrpdrpGKGSYWALHP 91  Lingula anatina
NP_001158435  13 KPPYSYIALTAMAIQSStekMLPLSDIYKFIMDRFPFYRkntqRWQNSLRHNLSFNdCFIKIPrrpdrpGKGSYWALHP 91  Saccoglossus kow...
BAQ19218      13 KPPYSYIALTAMAIQASgekMLPLSDIYKFIMDNFPFYRkntqRWQNSLRHNLSFNdCFIKIPrrpdrpGKGSYWALHP 91  owl limpet
ELT97594      13 KPPYSYIALTAMAIQTApdkMMTLSEIYKFIMDRFPYYRdntpRWQNSLRHNLSFNdCFIKIPrrpdrpGKGSYWALHP 91  Capitella teleta
NP_001027695  13 KPPYSYIALTAMAIQSSpnkMMSLSEIYRYIMDRFPFYRnntqRWQNSLRHNLSFNdCFVKVPrrgdqpGKGSLWSLHP 91  vase tunicate
ABA03229      13 KPPYSYISLTAMAIQSSpqkMLSLSEIYQFIMDHFPFYRdntqRWQNSLRHNLSFNdCFVKIPrrpdqpGKGSLWALHP 91  starlet sea anemone

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