3WVF,3BS6,5MG3,3BLC


Conserved Protein Domain Family
EcYidC-like_peri

?
cd19961: EcYidC-like_peri 
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Escherichia coli and similar domains
This subfamily is composed of Escherichia coli YidC and similar proteins. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contain a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich.
Statistics
?
PSSM-Id: 411000
Aligned: 1464 rows
Threshold Bit Score: 67.3376
Created: 12-Oct-2018
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
 
oligomer
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Structure:5MG3: Escherichia coli YidC interacts with SecYEG protein-conducting channel and the accessory proteins SecDF-YajC to form the bacterial holo-translocon (HTL); contacts at 4A
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
3WVF_A     59 KLISVKTDvLDLTINTRggDVEQALLPAYPkeln-stqPFQLLETsp------qfIYQAQSGLTGrdgpdnpangpRPLY 131 Escherichia coli U...
5MG3_C     64 KLISVKTDvLDLTINTRggDVEQALLPAYPkeln-stqPFQLLETsp------qfIYQAQSGLTGrdgpdnpangpRPLY 136 Escherichia coli
PPR08732   70 KPVEMQTEnYDVQLDLVggKITKLDLLNYVevk--dedKLVSIFSpkd-----eeSKVGMLLDAGwlsnkfstpdaNTVW 142 Proteobacteria bac...
PAW67582   84 QTAILESStLRVVLTTWggGIREIELRGHGaege-kgeETVHLNLgsp----daiFELRGWTPPGe----------GLAW 148 Verrucomicrobiae b...
OLD59653   68 RLAVVETPmYSAVVSSEggKLQELVLKYRGa-------KPMVIVGd--------lGPAGLLVSADgqsp----svvPMTL 128 Gemmatimonadetes b...
KYF90146   53 EACVIDGPrFKAELSTRggSLRHLWMTDPKyttgdgerRPMDLVTtslesrmplrTDLHLPGGNAqqv-----pfdDLDW 127 Sorangium cellulosum
RMD99496   78 EIVPYENEhYLVELSSLggSLKAWRLKHYYdslg-kdrKRVVLFDeke----pgnYLGQFRLGGSgfl-----etsLVPY 147 Deltaproteobacteri...
TFG94835   94 TLVPLETPlFRAELDSLgaTLRHYELVAYRatps-pasAPIVLTTgqp----pfaNALATPFRELglg-----dlsQVPF 163 Myxococcales bacte...
TMA33108  100 QSIEIARPlYLAQLSSEgaSLRDWELKGYRdr----reEPIRLVSasd-----avATAATPFAELalg-----dlsKQPW 165 Deltaproteobacteri...
PYN89957   70 RLATVESPlYRAVVSSEggKLQELVLRYRGe-------KPMVIVGdl------gpAGLQLAPGGNspg-----evvPMSF 131 Candidatus Rokubac...
Feature 1                                                                                     
3WVF_A    132 NVEkdayvlaegqNELQVPMTytdaa--gntfTKTFVLKRgDYAVNVNYNvqnagekpLEISTFGQLKqsitlpphldt- 208 Escherichia coli U...
5MG3_C    137 NVEkdayvlaegqNELQVPMTytdaa--gntfTKTFVLKRgDYAVNVNYNvqnagekpLEISSFGQLKqsitlpphldt- 213 Escherichia coli
PPR08732  143 SVDsk------gaDSVVLSYKndk-----ltfYRTFLFNKdNFLTNIEDK--------VINNSNEAIQiahysqihhi-- 201 Proteobacteria bac...
PAW67582  149 NLEr--------aDGAEVVLTapaqvggdvwiRRTFRLTG-DYDLNVVQE--------VENRGQVPLAlpayalsagvga 211 Verrucomicrobiae b...
OLD59653  129 SAEritl--gpgrSTQDLVLTgevd---glrvRQRLTFRAdDFAIEVSLR--------AENVARAPRAvtvslpwl---- 191 Gemmatimonadetes b...
KYF90146  128 KLSa--------qDGKSCTFTytde---atrlTKVVAATGrPFELSLQVT--------VENLAQEPRKhrlaveqtawrt 188 Sorangium cellulosum
RMD99496  148 EPLp--------iQGEKIAFRwktpg--gvqvTKTYTFNE-DYSATLAIS--------IENRSEEAVSgipeiflsrdfg 208 Deltaproteobacteri...
TFG94835  164 EIEr--------aDAHEVVFSfera---gvrvRKVYSFEPdSYAFSLRIV--------VENGSDAAIGpryavtwpa--- 221 Myxococcales bacte...
TMA33108  166 RVEn--------rSDTEVRFAwesh---gvalRKTFSFSDdGYDFRLRID--------VSNHGSTAIApaflvempllt- 225 Deltaproteobacteri...
PYN89957  132 DKDalf----itdKPGELVLSgeaa---glkiRQTLRFHPdGYAIDANIR--------VENPGAAPRTtvlsfpwftr-- 194 Candidatus Rokubac...
Feature 1                            #              #              #  ##                      
3WVF_A    209 -------gssnfalhtfrGAAYSTPd------------EKYEKYKfdtiadNENLNISs-------------kGGWVAML 256 Escherichia coli U...
5MG3_C    214 -------gssnfalhtfrGAAYSTPd------------AAYAAYAfdtiadNENLNISs-------------kGGWVAML 261 Escherichia coli
PPR08732  202 ---------geredklanSFTNFTGpe---------amIDAEKTQad---yKDLQDGQsfev--------egkNVWAGVT 252 Proteobacteria bac...
PAW67582  212 pihlrteeeayvgtgwltTDGTYTThklp-----efidSRFLFLFpq--kgKELATSRed-----------rsVKWVAAK 273 Verrucomicrobiae b...
OLD59653  192 -----------trqvwhaTHEKFQGqhptei--vwssnGHVERITd----lTAVHEHIa-------------dGEWIAME 241 Gemmatimonadetes b...
KYF90146  189 qk--eteghlglisewitETVAATD-------------QKTERQHpdafepGDFKDKEftperw---rrtpgnGRFAAVS 250 Sorangium cellulosum
RMD99496  209 -------teahqrsrfipGPLVFAE-------------KKLHKPRl-----KELRKEPvtff-------pashVQWFGFD 256 Deltaproteobacteri...
TFG94835  222 ----------svqpgndfTEQSFAVlh----------eGSMTREPl-----AGFGKSGffggsptteavfrreVDWAGIV 276 Myxococcales bacte...
TMA33108  226 --------ragndfreqsAAALHAGsvvrtpltslgsaGIFGWVSg-----KKGGEPVeyt----------gdIDWAGVQ 282 Deltaproteobacteri...
PYN89957  195 ---------qtwratpekFQGQHPT-------------EIVVATQgsvnriDDLVAAYniv----------adGDWIALD 242 Candidatus Rokubac...
Feature 1                                ###                                                  
3WVF_A    257 QqYFATAWIPHNdg-------tNNFYTANLgn------------gIAAIGYKsqpvlvqpgqtGAMNSTLWVGPEiQDKM 317 Escherichia coli U...
5MG3_C    262 QqYFATAWIPHNdg-------tNNFYTANLgn------------gIAAIGYKsqpvlvqpgqtGAMNSTLWVGPEiQDKM 322 Escherichia coli
PPR08732  253 RqYFAGAIIPDNan------tnTVKIKHNKvgedny---ytvlvrSHVKSLEag-------anLTEKFQVYAGPKsTKIL 316 Proteobacteria bac...
PAW67582  274 SqFFAMVLTALEspasg-aearKVELKGAKmrdggg----pvgaiETWMKLPgfdlv--aggkNVRTFGLYAGPKeDWRL 346 Verrucomicrobiae b...
OLD59653  242 SvWYLAALVPKTeg-------fKLVVTSEGkppepkn-gdtapagRASIALRaapai-apgqaWEGRILLYAGPKeYERL 312 Gemmatimonadetes b...
KYF90146  251 SsYFSKIAIPLEgpgqpaaetqIEEIWDTSrfpqkskdpshghvyRARLAYPehela--pggaVTYKVLSFTGPKeRDLL 328 Sorangium cellulosum
RMD99496  257 KkYFLTAVVPLEqenv---tttLRNLYGDRvqi---------qttSAARTVApg-------etLTLSYMIYGGPKkLDLL 317 Deltaproteobacteri...
TFG94835  277 TtYFVAAVIPEDpv------qaSGQFVATEparag-----vvqvfFDPVMLPpg-------qnAERIFRVYAGPKeAERL 338 Myxococcales bacte...
TMA33108  283 TpYFLAAFFPDQpd------taRTRFVSLMpgkq-------gvvqIYFDPVAlqp-----tqsATREYRAYFGPKeIERL 344 Deltaproteobacteri...
PYN89957  243 SvWYLAALVPKApgfkv-vaatDGKLPDAKtgdt-------tpagRATIAVRatpti-gpgqaWEGNVVLYAGPKeYDRL 313 Candidatus Rokubac...
Feature 1                      
3WVF_A    318 AAv----aPHLDLTVDY 330 Escherichia coli UTI89
5MG3_C    323 AAv----aPHLDLTVDY 335 Escherichia coli
PPR08732  317 EEqpvakeIRLPSMLDY 333 Proteobacteria bacterium
PAW67582  347 RRl----aHGEDEVMEF 359 Verrucomicrobiae bacterium Tous-C5FEB
OLD59653  313 RA------HGLQETINF 323 Gemmatimonadetes bacterium 13_1_20CM_69_28
KYF90146  329 AAv----dHGASEVINL 341 Sorangium cellulosum
RMD99496  318 EQk----dFGLSHAISF 330 Deltaproteobacteria bacterium
TFG94835  339 EAv----gAGLIRSIDL 351 Myxococcales bacterium
TMA33108  345 EAf----aPSAAASIDL 357 Deltaproteobacteria bacterium
PYN89957  314 KA------LGLQDTINF 324 Candidatus Rokubacteria bacterium

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap