3WVF,5Y82,5MG3,3BS6,3BLC


Conserved Protein Domain Family
YidC_peri

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cd19960: YidC_peri 
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Gram-negative bacteria and similar domains
Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contains a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich. Other members of the YidC/Oxa1/Alb3 family include YidC1/YidC2 from gram-positive bacteria as well as eukaryotic members such as mitochondrial Oxa1/Oxa2 (or Cox18) and chloroplastic Alb3/Alb4; they are not part of this hierarchy as they do not possess the periplasmic domain.
Links
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Statistics
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PSSM-Id: 410999
Aligned: 41 rows
Threshold Bit Score: 99.6325
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3WVF_A    59 KLISVKTDvLDLTINTRggDVEQALLPAypkelnstqPFQLLETspqfiyqaQSGLTGrdgpdn--pangpRPLYNvekd 136 Escherichia coli UTI89
5MG3_C    64 KLISVKTDvLDLTINTRggDVEQALLPAypkelnstqPFQLLETspqfiyqaQSGLTGrdgpdn--pangpRPLYNvekd 141 Escherichia coli
3BS6_A     4 KLISVKTDvLDLTINTRggDVEQALLPAypkelnstqPFQLLETspqfiyqaQSGLTGrdgpdn--pangpRPLYNvekd 81  Escherichia coli
3BLC_A    35 KLISVKTDvLDLTINTRggDVEQALLPAypkelnstqPFQLLETspqfiyqaQSGLTGrdgpdn--pangpRPLYNvekd 112 Escherichia coli K-12
OHD93961  75 DIVTVTNDkFVLKIDTLg-RISSKELLQekfr--dqnNKHAQLIpt----lgAKPLYVrfldealnkeaatVAYTAdvre 147 Sulfurimonas sp. GW...
PRY18858  81 SIVTIKSDnFVLKLDTLg-RISSKILLEdkfn--nsdDLHAEVVsp----tgAKPLYVrfaddvlnneaisTAYTAsvse 153 Epsilonproteobacter...
PHR56686  79 ILARLNGEnYILTIDTLg-RISQKEMLEekfa--deeTGHAKLVad----vgAKPLYIrfadkalnkeamtTPYTSnvka 151 Arcobacter sp.
KIM10251  77 TLVTLKSAhYTLKIDALg-RISSKELYEkryl--pegATKLEMIsq----tlPKPLEMrfntpelnneafkVAYTAsise 149 Sulfuricurvum sp. P...
ADN09714  80 NIVTIKNKnFILKIDTLg-RMSSKELLEdkfr--ntdNLHAQVIps----tgTKPLYIrfaedaindeatkVPYTAnvse 152 Sulfurimonas autotr...
EJF06851  78 KLVTVKSKdFILTIDNFg-RISTKTLLGekyk--ndkGVQAQLVtk----fsPKPLEIrfedvdlnllafkNEYKSdkma 150 Thiovulum sp. ES
3WVF_A   137 ayvlaegqNELQVPMTytdaagntfTKTFVLKRg-DYAVNVNYNvqnagekpLEISTFGQLKqsitlpphldtgssnfal 215 Escherichia coli UTI89
5MG3_C   142 ayvlaegqNELQVPMTytdaagntfTKTFVLKRg-DYAVNVNYNvqnagekpLEISSFGQLKqsitlpphldtgssnfal 220 Escherichia coli
3BS6_A    82 ayvlaegqNELQVPXTytdaagntfTKTFVLKRg-DYAVNVNYNvqnagekpLEISSFGQLKqsitlpphldtgssnfal 160 Escherichia coli
3BLC_A   113 ayvlaegqNELQVPXTytdaagntfTKTFVLKRg-DYAVNVNYNvqnagekpLEISSFGQLKqsitlpphldtgssnfal 191 Escherichia coli K-12
OHD93961 148 i---nlqtQAQKIILTqtls-slsvTKELTFYPdgHYDVAIKLS--------KDTRYFIYLGqrpeite---------qm 206 Sulfurimonas sp. GW...
PRY18858 154 a---iikdKPVQVVLTqklq-dlivTKNLTFYAdgHYDVNIVLS--------RDARYFVYIGqrpevsk---------ql 212 Epsilonproteobacter...
PHR56686 152 a---nlvdGHVSVILTqkls-sltvTKNLTFYAdgHYDINIKLS--------EDKRYYVYLGmhptfsd--------kqm 211 Arcobacter sp.
KIM10251 150 a--titadAPVDVVLTqqls-gvtvTKKLRFYEagNYDIDVSLS--------DEKAYSIATGfqpninl---------dg 209 Sulfuricurvum sp. P...
ADN09714 153 v---slkdKPVTVTLTqkls-altvTKVLTFYTdgHYDAKISTS--------KDVRHYIYLGdrpkvsk---------kl 211 Sulfurimonas autotr...
EJF06851 151 i---dvshTPQKVVLTqvld-evivTKKLTFYPagNYDVKIEVT--------GGKRFFVSNGmrpdvne---------fg 209 Thiovulum sp. ES
3WVF_A   216 htfrGAAYSTpdekyekykfdtiadnenlnisskgGWVAMLQqYFATAWIPHNdgtnnfytanlgngiaaigyksqpvlv 295 Escherichia coli UTI89
5MG3_C   221 htfrGAAYSTpdaayaayafdtiadnenlnisskgGWVAMLQqYFATAWIPHNdgtnnfytanlgngiaaigyksqpvlv 300 Escherichia coli
3BS6_A   161 htfrGAAYSTpdekyekykfdtiadnenlnisskgGWVAXLQqYFATAWIPHNdgtnnfytanlgngiaaigyksqpvlv 240 Escherichia coli
3BLC_A   192 htfrGAAYSTpdaayaayafdtiadnenlnisskgGWVAXLQqYFATAWIPHNdgtnnfytanlgngiaaigyksqpvlv 271 Escherichia coli K-12
OHD93961 207 mtvsGAMVYTnddlvtiiedg---daqgrktfsgvELISAFDqYFASIMYGFSadtnimvekdk----------ndnpvv 273 Sulfurimonas sp. GW...
PRY18858 213 mavaGGMVYTddeiatiiedg---daegrkvfsavTLASAFDqYTASIMYGFKkdtniivdrdr----------sdnpvi 279 Epsilonproteobacter...
PHR56686 212 msveGVMVDTgsdhlinivedg--dasnmtsyndvNLVSSFSqYFASIFYSLDkdttvkvdrdr----------ddnpva 279 Arcobacter sp.
KIM10251 210 ftlhGVLVEQgndiltiiedg---eagatqsfndvKLASSFDrYYANLFFTNDanmraiiaptld--------gqenpml 278 Sulfuricurvum sp. P...
ADN09714 212 mavaGALIYTdddvahiiedg---daegrqvfqgvKLASSFDqYTAIILYGFTkdtniivergk----------ddnpvv 278 Sulfurimonas autotr...
EJF06851 210 fvvqGAMVKVgdqitiieded----argtsifrdvMFLSSFDrYYASIFYNLAptqniviegdk----------fenpmv 275 Thiovulum sp. ES
3WVF_A   296 qpgqtGAMNSTLWVGPEiQDKMAAvapHLDLTVD 329 Escherichia coli UTI89
5MG3_C   301 qpgqtGAMNSTLWVGPEiQDKMAAvapHLDLTVD 334 Escherichia coli
3BS6_A   241 qpgqtGAXNSTLWVGPEiQDKXAAvapHLDLTVD 274 Escherichia coli
3BLC_A   272 qpgqtGAXNSTLWVGPEiQDKXAAvapHLDLTVD 305 Escherichia coli K-12
OHD93961 274 yfealASTSFHGYVGDKdFETLKNinpVLTNAIE 307 Sulfurimonas sp. GWF2_37_8
PRY18858 280 yfeatPNSTFNGYLGPKeHKVLKAinpALVNAIE 313 Epsilonproteobacteria bacterium SCGC AD-311-E16
PHR56686 280 fveglQDFTFNGYIGPKdYLILEGinpELVNAIE 313 Arcobacter sp.
KIM10251 279 fiegkPAMQFHGYVGPKeYRTLKAidpLLVDSLE 312 Sulfuricurvum sp. PC08-66
ADN09714 279 yfdarKDENIHGYIGPKeHKILKAidpVLTNAIE 312 Sulfurimonas autotrophica DSM 16294
EJF06851 276 fveglQQVNFSAYLGAKdFEILESlnpKLTDAIE 309 Thiovulum sp. ES
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