5HDT,5FRP,5FRS,5F0N


Conserved Protein Domain Family
PDS5
?
cd19953: PDS5 
Sister chromatid cohesion protein PDS5
Pds5 plays a crucial role in sister chromatid cohesion. Together with WapI and Scc3, it is involved in the release of the cohesin complex from chromosomes during S phase. The core of the cohesin complex consists of a coiled-coiled heterodimer of Smc1 and Smc30, together with Scc1 (also called kleisin). Pds5 interacts with Scc1 via a conserved patch on the surface of its heat repeats. Pds5 also promotes the acetylation of Smc3 that protects cohesin from releasing activity in G2 phase.
Links
?
Statistics
?
PSSM-Id: 410996
Aligned: 151 rows
Threshold Bit Score: 381.102
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
  next features
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:WapI binding site [polypeptide binding site]
Evidence:
  • Structure:5HDT: Human Pds5 with bound WapI peptide, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #                                          ##  ####             
5HDT_A      22 XVRRLKXVVKTFXDXDQDSEee--keLYLNLALHLASDFFLKHPdKDVRLLVACCLADIFRIYAPEAPHtspDKLKDIFX 99   human
GBG74693    33 ILQNLKAANTMLMDIPQSASqaa-saGVNACAAALAQRQLLHHRdKEVRLFVASCLSDILRVSAPEAPYe-dTVLKDIFS 110  Chara braunii
KMZ60117    26 IVKLLKEASSVLSALEQSLEle---yALLPLNNVLVQNSFLLHKdKEVRLLLAVCFCEIIRILAPKPPFs-dEVFKGVFK 101  Zostera marina
GAQ90116    30 LLKTLKQGSGLLAELGPVASpsv-knTIKPFVEALGQQSIVRHKdKDVKLLAASCISEVLRLCAPDAPYe-dPTLKDIFR 107  Klebsormidium ni...
KUG00125    95 MWQTLQKTSSKLQQREDGVLdvnatrQLQLVAAELLQNKLLQHQdALVRSLVACCLVEIMRISAPDSPFasdEDLYRVFK 174  Phytophthora nic...
RHZ38691    36 VARRLKTELQRLRGTVNGELdk---nDSTALGREFTSESYLEHSdPHVRLLVASCIAELLRVTAPDTPFgsdHELYEVFV 112  Aphanomyces astaci
EWM25805    30 LAKRLKEVWEHLTTLSQDDRp----tGLEGSTKALGSSRILDHTdKDVRLYTACALAEILRIYAPEAPFs-sPVLLQGFA 104  Nannochloropsis ...
CCI42822   135 SIPNISHAAYELQEKSVSPD------DLRLLSSEILKDDVMETRdKNARSRIACCIVELLRVYAPESPFpskQHTCTAIQ 208  Albugo candida
OUS42443    35 AGKILEALADALSKVDQGGEga---kALLDTTKALTTRFVMTHEsKRVRVLTALCVSDIMRVCAPDAPIegdEAMRDVYE 111  Ostreococcus tauri
GAX25627    43 LKRHLQKLLHVLQTDETIECds--rqWPGLAAVAERLPQLFQHNdKQVRLLATACSLEILCLYAPNVPWd-dEVLLEFFR 119  Fistulifera solaris

Feature 1                                            #### ## ##                                
5HDT_A     100 FITRQLKGLedt----------kspQFNRYFYLLENIAWVKSYNICFELed----------snEIFTQLYRTLFsvinng 159  human
GBG74693   111 LMVSIFHGLddl----------qspLFSRRVSILESMATVRICVVMLDLdc-----------dDLILELFTSFFdtispe 169  Chara braunii
KMZ60117   102 LIISTFKDLadi----------dspFFAWRVKILEITATLKCCLLMLDIgc-----------eDLVLEMFNIFFsvvrvd 160  Zostera marina
GAQ90116   108 LFTSVFEGLnev----------tgsSYLKRVAVLESLAKVKSCVMILDLdd-----------eELVLRFMETLFdvihid 166  Klebsormidium ni...
KUG00125   175 LLIEQIRXLsseq--------tttsRDLHHFHVLESLATAKSCLLVVSLdfttv-----etesRVMVQLFDALFdtlqed 241  Phytophthora nic...
RHZ38691   113 LLVRVLRETtk-------------hTDIAWFTLLETLASVKMCNLAVGLtpdsshaqsdvspeDLVVDIFRCLFeriqdd 179  Aphanomyces astaci
EWM25805   105 LITAQLRSLvsvpgkqaqaaaacghKPVPVLYLLHSLATVKSCIILSELvqqdl-----praeEELVDFFSCLLgsvred 179  Nannochloropsis ...
CCI42822   209 FILEQLVALsqestaratsvgakssLDFQFYHILESLSDLKVCILVSRLnspne-----egepTLLVRFAQAFFelirpe 283  Albugo candida
OUS42443   112 LFLDALGSLksi----------eseEFESAKSLLMNIANIGLCVPMLDLecd--------gadTLVRDLFRVLLdavnas 173  Ostreococcus tauri
GAX25627   120 QLLRQLGNLshtln-------aeqpNYTIYLHMLSQLAVVKVGAVLTDEamer------paalEVLVEFLHTLLhsirhk 186  Fistulifera solaris

Feature 1                        #                                                             
5HDT_A     160 hnqkvHXHXVDLXSSIICEgd----tvSQELLDTVLVNLVpahkn--------------------lnkqAYDLAKALLKR 215  human
GBG74693   170 hprtvAKSMVGVMTILLEDrd----eiPQQLLDSILCSLLkrkre--------------------espaAYSLAQQLLQS 225  Chara braunii
KMZ60117   161 hqeslVKSILSVLIIIIEEs------iCFPLMDIIFRNLLkdkkg--------------------gssaSFKLAVSVIQN 214  Zostera marina
GAQ90116   167 qarnvRMAILEVLAILIDEse----dvTQPFLDLILSYLFspkkn--------------------dnpaAAQLAQALLKR 222  Klebsormidium ni...
KUG00125   242 hsakvENLMLTIMVACIEEsd----evEQSLLGVILRPLVngansqlen-----------endgqnatsPCHMAKELIRR 306  Phytophthora nic...
RHZ38691   180 haakvEANMVSIMVGCLEEcd----vvSPQLLETLLEPLLhndq----------------------hprAYHMAQQVIEK 233  Aphanomyces astaci
EWM25805   180 hplelREQILDILTACLAEle----vvPQALLDTVLLCLLpehka--------------------esspSYQLTQLFVAR 235  Nannochloropsis ...
CCI42822   284 hsnrvHNLMISTLVTIIEEse----siDQSFLEALLVPLVhnrstegige---------lqkdsspesgPYYISREVIYR 350  Albugo candida
OUS42443   174 nsttvTEEISKVLTTMIEEscdedtpvPADIVFEVLSRLIdpvrt--------------------enpaSYRLAVELVRK 233  Ostreococcus tauri
GAX25627   187 hssavMDLAQEAIGVCLDEyh----qaSLPVPVVLLDELLiavgqgpttqitelhpetklpqavavpnpTHRIAAALLQA 262  Fistulifera solaris

Feature 1                                                                                      
5HDT_A     216 taQAIEPYITNFFNQVLxlgkt---------sisdLSEHVFDLILELYNIDSHLLLSVLPQLEFKLksnDNEERLQVVKL 286  human
GBG74693   226 caDVLQPYVQRFLLSVIvdgrg---------geseLVEHYHELIYEIYQVAPQVLITVLPSLAQELevnQVDKRLKTIRL 296  Chara braunii
KMZ60117   215 sgDKLQSFVSQFLISCIlerdi---------tdhkFEELYHKITIELYKCSPQILVEVLPYFVQELvagQINVRIKAMQL 285  Zostera marina
GAQ90116   223 evEVLRNPLQQFLLSVMlkgk----------sqseLKKDYHDIIYEVYRAAPQLLMTVLPNLEGELqvdQVETRLKAIDL 292  Klebsormidium ni...
KUG00125   307 tsEILQNPLSNFFNNILvdgpgl-------qqsseLKEHVYTLIYEVHKISPSLLLYVLPNVCLQLqvdEVATRSDAIAL 379  Phytophthora nic...
RHZ38691   234 asDQLQNALSLFFNSVLvdattph----slsttsdMKDHVHTLIYETHKIQPGLLLYVLPNVCLQLqvdDMETRSNAIAL 309  Aphanomyces astaci
EWM25805   236 cfAELNPPVTAFINQVLtgkgc--------gvseiEEEHVHPLIYELHKVNPNFMLYIFPNVATQLaaeDTAVRARAVAL 307  Nannochloropsis ...
CCI42822   351 tsESLQTFLAQFLNNFLiednrde-----drksseVRENLFSVIFELHKICPSLLLYILPNICVQLqadGIATRLKVVSL 425  Albugo candida
OUS42443   234 ceHQLHTPIQNFLTEAMhgsvde------dsalapLSKRHVDVIEEIAVCDPTALVTVWPSVTDDLqadDLSVRLRAVKL 307  Ostreococcus tauri
GAX25627   263 q-VHLQMPVSQLINGLLtndtlaleqssiskdsesETVHLYKIIYHLYAVVPQYLTTVLGTLAQGLssdDTPQRQAVTYW 341  Fistulifera solaris

Feature 1                                                                                      
5HDT_A     287 LAKXFgakdselasqnkPLWQCYLGRFNDihVPIRLECVKFASHCLxn--------hPDLAKDLTEYLKVRSHDpe-eAI 357  human
GBG74693   297 LARLFsipgkntaneyqQLFTDFLKRMNDkdLEVRLEMAKLAKSVLpcl-----psnSAESKELLEELISRVMDyd-yEA 370  Chara braunii
KMZ60117   286 VAEIFvlskmhatqeypLLFTEFIRRISDksSEVRNFALECAKTCYmsn------ttSTASSGILGALEGRLLDfd-dNV 358  Zostera marina
GAQ90116   293 LGKIFcipgdqaateyrPLYNEFVLRFNDkaVEVRAKMVQWAQQFLps-------apDAQAKEISDNLLQRLKDyd-dKI 364  Klebsormidium ni...
KUG00125   380 MGKLFasshadyghqymKNFRDFLGRFRDasKEIRLQMIQLSVRIWek--------kPDLADLLEKEFILRLSDpe-wEV 450  Phytophthora nic...
RHZ38691   310 MGRLFasshadyghqylKNFREFLGRFRDvkKEIRLQMVTVCSIVAqr--------kPDLALLVDAELQLRLQDpe-wDV 380  Aphanomyces astaci
EWM25805   308 FGRLFaalhadygneypRIFREFLGRFKDkdASIRAQVLGIGAVIMqr--------kPKLAEQVAPLLAARLQDpe-wEI 378  Nannochloropsis ...
CCI42822   426 LGKLFaspdteygaesmRLFREFLGRFRDisQEIRLNMIQLGVMIWqe--------kRDLAPLIENECILRLSDse-wEV 496  Albugo candida
OUS42443   308 FGRVFafaesrtaedypHLLLEFARRFNDkaVEVRLEMVKWSPKFLksrvdphaeltSVPAATIVKQLRERLHDfd-eSV 386  Ostreococcus tauri
GAX25627   342 WGKLLllht----qqrqSFLSLWLPRAKDihAPIREIVIRACVPLLrslsvsktavaHDDHKEIEHVLQEVVMSdpakSV 417  Fistulifera solaris

Feature 1                                                                                      
5HDT_A     358 RHDVIVSIVTAAKKdill--vndhLLNFVRERTLDKRWRVRKEAXXGLAQIYKKYAlqsaag------------------ 417  human
GBG74693   371 RSMAVKMMCELAIAkprl--ipcdKLQNVSDRLRDKKVSVRKEALKSFTELYASHClrsfeg------------------ 430  Chara braunii
KMZ60117   359 RIQAMTIVCDLAMSdlns--fpseLVLQAYERLRDKKVTVRRKTMQKLLQLYHVYCqrcskg------------------ 418  Zostera marina
GAQ90116   365 RSQAAVAACEVASVnpda--vsaeLLMAAADRMRDKKVFVRKDALKAFTQLYSKQVtwvtqg------------------ 424  Klebsormidium ni...
KUG00125   451 RQLVVHELCDFAANcldl--iseeCLRAVGERMKDKKVVLRKETMTGLSQVFSAHIssywedeerlls----------ln 518  Phytophthora nic...
RHZ38691   381 RRLVVNELCDLATHslas--vsnaSLREVGERMKDKKVVIRKEAMTGLAQIYAAHVstswtngn---------------- 442  Aphanomyces astaci
EWM25805   379 RAKTVREVCQTALQsiel--vsktLLKEVGGRLADRKPQVRLEVIRGLATLYAAYIsrtwseaerl-------------- 442  Nannochloropsis ...
CCI42822   497 RRAVVNEVCDLSANhlei--vseeCLRQVGERLKDKKLIIRKEAMTGLSQVYAHHVsaywarsknqpne---------rl 565  Albugo candida
OUS42443   387 RSTTVSVLCDLLDAptstdlfpleFLLEIGERIKDKKSIVRKVTLKRLCISYRAYAqrcsdda----------------- 449  Ostreococcus tauri
GAX25627   418 RLLAVHELCDAEYNqagt--vsskLLQAVASRIPSKDAAERKDALTGLAQIYAKHGalqenlqsgleilpgrkrklssrd 495  Fistulifera solaris

Feature 1                                                                                      
5HDT_A     418 -----kdaakQIAWIKDKLLHIYYqn---sIDDRLLVERIFAQYXVPhnlettERXKCLYYLYATLDlnavKALNEXWKC 489  human
GBG74693   431 ----kglpdeQFEWIPGRIIKCYYd----rDLRLETTQVLLDEQLFPpqlpveERAKHWVSMFAAFDemsrKAFDVLLVM 502  Chara braunii
KMZ60117   419 ----lfsyneKFEQIPSKILTLCFnkv-ckEFRPQNMDIFFAEDLFPtslsaeNKANHWMAFFSFFTpshnKALNSMLTQ 493  Zostera marina
GAQ90116   425 ----qsvddsKFAWIPARLVRLVYd----kDIKYQHIQNVFEEELFPvktpveQRARHWVSMFSTVDdverKGLGFIMTL 496  Klebsormidium ni...
KUG00125   519 qrnipaenikKLGWIPDFVLKCYAyp---qQELKLRVIQLVDDFLLPkalsehTRANGLLFLFHSLDdtskEALRRIFSE 595  Phytophthora nic...
RHZ38691   443 --kdatavaqQLAWIPEYVLKCFAyp---iQELRLRVVQLVDDILLPksstelFRMKGLLFMWKTLDagsrEALRRVFLE 517  Aphanomyces astaci
EWM25805   443 hdtlpqdleeKLGWIPGTVLLGYSlp---dSELRLSILQVFDEVMLPkaadcqVRTTGLLFMWHRLTadanRALRAVLQD 519  Nannochloropsis ...
CCI42822   566 ldvipkdclkKLGWIPDYVLKCFAyp---qQELRLRVVQLLDDYILPkafdvkIRAKGFLFLYQHLDdvsiEAFRRILQE 642  Albugo candida
OUS42443   450 ----pawetkRFDWIPCALLRAITi-----PDVRLHAVEPVLASMFPakmsadVRSTFWLRALNLADaftiRCLKHLLLA 520  Ostreococcus tauri
GAX25627   496 peddeddeegSYDWIPRKLLEACHfsdkldSALRSRLYQIMDDVLVGkq---sRPAIALVWMMQHLDdsalQSWLSLLKG 572  Fistulifera solaris

Feature 1                                                                                      
5HDT_A     490 QNLLRHQVKDLLDLIKqpkt-----------dasvKAIFSKVXVITRNLpdpgKAQDFXKKFtqv--ledDEKIRKQLEV 556  human
GBG74693   503 KQRLQQELQAYLDLRQqqkddq--------stdmrNKVNTSLQRILGLSvdpsKGMEHLQKLhq----ikDNRVFKLLGS 570  Chara braunii
KMZ60117   494 KRRLQKEMRAYINLQEkkkens--------sedlhKTILVSLANMNTYFldpyKSEEGFRNLyq----mkDNHIFRDLLK 561  Zostera marina
GAQ90116   497 KQRAQQEMRTYLEVRQllkenp-------tdketqDRKTAAFRSLSTNFvdpnKAMEHLAKLdq----lkDNAIFKGLAQ 565  Klebsormidium ni...
KUG00125   596 RAKCQQVCRKFVEFKVqnrhkgrat--dgddaaleQAKQLLCDGLSPLFsdvsRLGKLVDKFsk----wkDHSVVKHLGE 669  Phytophthora nic...
RHZ38691   518 RVQCRQIIQQFLALKQqlrqgn--------aanngSSLQKCLKELSPLLpeteGLTGLVDKLat----wkDLKLVKHLGV 585  Aphanomyces astaci
EWM25805   520 QAMVQALVNEYLAARSswradmddelrevrlqecgEALLEAVPVLDRRA----SGTSLPLKLne----tkDQQAPKLLQT 591  Nannochloropsis ...
CCI42822   643 RVKCIQACQEYIDTRTmlrqtkg-----spitsyqNITRAFRDEIAPMF----NETDHLDKLmdqlnswkDQTVFRALSS 713  Albugo candida
OUS42443   521 KAQMQADMREYMMIRSklsgmn--------kkdgeAALAKIFDAIKVHFsdqhKAKDAMMSLha----qkDGNIFRCIQT 588  Ostreococcus tauri
GAX25627   573 RFEVQRLLSKYLQLRSqakrd----------egadAVAYQALQGTAALLpt-pKSEQFLEKLhk----akDQHMFRILAG 637  Fistulifera solaris

Feature 1                                                                                      
5HDT_A     557 LVSptcsCKQAEGCVREITKKLgnpkqptNPFLEXIKFLLERIApvhiDTESISALIKqvnksidgtaddedegvpTDQA 636  human
GBG74693   571 LLDhnttVAEAKTIKEELLKRLge----kHPQREFLRTLASRVSytmfGKEHVNAIFKavkdc---------efekNREL 637  Chara braunii
KMZ60117   562 LLDeqttYTAFRNIQDSFLKRIgk----kHPYYSFFKELSFRCSnsifTEEHVLYFLKsyisk---------kksiSKHT 628  Zostera marina
GAQ90116   566 LLDvgvsMVAAKKAQEDVLKRLgq----kHAQHDFLKALAQKVSytliSKDLVTAILGllse----------rgglGPSL 631  Klebsormidium ni...
KUG00125   670 LCDfsktQREARQARDQLVRSVgs----kTPLGEFLKKLCRKLSlltmSQTSVAVLLDflvl----------kearPARE 735  Phytophthora nic...
RHZ38691   586 LCAatsdAAAIRQAREDIVKMVgs----kTPLGDFIKNVCRKLAmttvNASSVDCLLSi----------------lKDEP 645  Aphanomyces astaci
EWM25805   592 IMDprqpSNRVLKARDDLAAKVgs----kSVLGEYVRVLARRATscfaNQETLADLIQlarelle----ngeggdeEENT 663  Nannochloropsis ...
CCI42822   714 ISDytksQKEIRASRDRLVKCVgs----kSALGAFIKDFCRKSNlltfSKESVDFFLEivrn----------sgrsTIRE 779  Albugo candida
OUS42443   589 ILNpetaFADAVKAEEDAIKRAkss--sqGVDLDFIKALLLKNQsapfGREHVRGTLKaackatrs--tqssktstAPQA 664  Ostreococcus tauri
GAX25627   638 ICDpnhaCSARKRAMEDLVARTkas--lgDDVADWMKQVVRRVAm---GNSVNETILEdcvvlaq-----emweeeHLVT 707  Fistulifera solaris

Feature 1                      
5HDT_A     637 IRAGLELLKVLSFTHP 652  human
GBG74693   638 LSGAMQLLVEIAGHFP 653  Chara braunii
KMZ60117   629 EATTFDLLYIILNITP 644  Zostera marina
GAQ90116   632 MKAAVDLLAAIASHFP 647  Klebsormidium nitens
KUG00125   736 NRSIVDLLVMASGELP 751  Phytophthora nicotianae
RHZ38691   646 THECVEVLHLVGSIFP 661  Aphanomyces astaci
EWM25805   664 LEGAVALTELLIESFP 679  Nannochloropsis gaditana
CCI42822   780 RQTALRIIALVAKVMP 795  Albugo candida
OUS42443   665 VIVALEHLCVLAETFP 680  Ostreococcus tauri
GAX25627   708 CSKVLECIHHIVGVFP 723  Fistulifera solaris

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap