Conserved Protein Domain Family
DSRM_DRADA_rpt2
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cd19914: DSRM_DRADA_rpt2 
second double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
DRADA (EC 3.5.4.37; also known as 136 kDa double-stranded RNA-binding protein (p136), interferon-inducible protein 4 (IFI-4), K88DSRBP, ADAR1, G1P1, or ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. Vertebrate DRADA contains three double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Links
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Statistics
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PSSM-Id: 380743
Aligned: 5 rows
Threshold Bit Score: 142.293
Created: 24-Oct-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative RNA
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on structure evidence that Homo sapiens TARBP2 (5N8L) binds siRNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # ##  ##  ##    ##          #### #                ####  ##             
P55265        613 KSPVTTLLECMHKLGNSCEFRLLSKEGPAHEPKFQYCVAVGAQTFPSVSAPSKKVAKQMAAEEAMKALHGE 683  human
ALX72796      556 KHPISVLMEYGQKSGNMIEFLLLSQDGPPHDPRFSYCVKMGDQIFPAVVGNSKKGAKQMAAEVAVKILSGE 626  chicken
XP_014344140  566 KNPISMLMEYSQKSGNTCMFQMIGQEGPPHDPKFTFRVKVGEQMFPVAVANSKKVAKQIAAENAVRVLMGE 636  coelacanth
AAF69672      742 KNPVSVLMEHSQRSGHPIQFIKTGQEGPSHDPRFMFRVKVGERLFQEASAPSKKAARQLAAEEAVKELMGD 812  zebrafish
NP_001081675  678 KNPISLLMEHGQKSGNMCEFQLVSQEGPPHDPKFTYTVKIGNQTFPPVVANNKKMAKHLAAEAAVRELLGE 748  African clawed frog

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