1DI2


Conserved Protein Domain Family
DSRM_PRKRA_rpt2
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cd19891: DSRM_PRKRA_rpt2 
second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
PRKRA (also known as interferon-inducible double-stranded RNA-dependent protein kinase activator A, PKR-associated protein X (RAX), PKR-associating protein X, protein kinase, interferon-inducible double-stranded RNA-dependent activator, PACT, or HSD14) is a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. PRKRA contains three double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Links
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Statistics
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PSSM-Id: 380720
Aligned: 5 rows
Threshold Bit Score: 127.749
Created: 24-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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RNA binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1DI2; Xenopus laevis PRKRA binds dsRNA, contacts at 4A.
  • Citation:PMID 9857205
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        # ##  #                     ## # #               ####  #           
1DI2_A         1 MPVGSLQELAVQKGWRLPEYTVAQESGPPHKREFTITCRVETFVETGSGTSKQVAKRVAAEKLLTKF 67  African clawed frog
EMP26370     145 NPIGTLQELAVQKGWRLPEYSLAHESGPPHKREFTMSCRIETFVETGTGTSKKLAKRNAAEKLLAKF 211 Green sea turtle
Q7ZYA5       123 NPVGSLQELAVQKGWRLPEYTVAQESGPPHKREFTITCRVETFVETGSGTSKQVAKRVAAEKLLTKF 189 African clawed frog
XP_006012627 124 NPIGTLQEIAVQRGWRLPEYGIAQESGPPHKREFTITCKVEKFEESGTGTSKKIAKRAAAEKMIAKL 190 coelacanth
O75569       126 NPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLAKF 192 human

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