Conserved Protein Domain Family
DSRM_STAU2_rpt2
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cd19882: DSRM_STAU2_rpt2 
second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen 2 contains five double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Links
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Statistics
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PSSM-Id: 380711
Aligned: 13 rows
Threshold Bit Score: 133.685
Created: 24-Oct-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative RNA
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on structure evidence that Drosophila melanogaster Staufen (1EKZ) binds a RNA hairpin.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                 #  ## ##                               
Q9NUL3        98 VELNGLAMKRGEPAIYRPLd----------------PKPFPNYRANYNFRGMYNQRYHC--------------------- 140  human
Q5M7M7       116 VELNGLAMRRGEPAIYRSLd----------------PKPLPNQRANYNYRGMYHQRYLC--------------------- 158  tropical clawe...
Q7ZW47        98 VELNGLAMKRGEPAIYRPLd----------------PKPIPNYRANYNFRGMFNQRYHY--------------------- 140  zebrafish
XP_014349083 170 VELNGLAMKRGEPAIYRPLd----------------PKPMPNYRANYNFRGMYNQRYHY--------------------- 212  coelacanth
XP_007885178 171 VELNGLAMKRGEPAIYRPLd----------------PKPMPNYRANYNFKGMYNQRYHY--------------------- 213  elephant shark
NP_001026112 170 VELNGLAMKRGEPAIYRPLd----------------PKPIPNYRANYNFRGMYNQRYHC--------------------- 212  chicken
ELT94341     189 VELNALAMKRGEPAVYRPIe----------------PNRPYFPPPNLDFRGMYNQRYHYp-------------------- 232  Capitella teleta
XP_006811959 165 VELNGLAMKRGEPAIYRPIeanp---------rgpqQGYYNRPPPNYNFRGMYNQRYRY--------------------- 214  Saccoglossus k...
XP_023933375 219 VELNALAMKRGEPAVYRPIe---------------pPRPACYGPPNLDFRGMYNQRYHYp-------------------- 263  Lingula anatina
EEN44004     169 VELNGLAMRRGEPAIYRPIdp--------------kPTIPPQYRPNYNFRGIYNQRYHY--------------------- 213  Florida lancelet
Q3L1C9       438 VELNALAMKRGEPALYKSIe---------------pQQPPYYHQPNMDFRGLYNQRYHQymrasrdpryrgngvlwplry 502  California sea...
KFM77620     198 VELNALAMKRGEPAVYQLI-----------------EPQRPQYIPNLNFRGMYHQRYHY--------------------- 239  Stegodyphus mi...
PNF27241     277 VELNALAMKRGEPAVYTFMepphhhgnhsgaphnpyVPPPVPPGHNFNYRGMYNQRYHHygks----------------- 339  Cryptotermes s...

Feature 1           ####                   #   #           
Q9NUL3       141 ---PVPKIFYVQLTVGNNEFFGEGKTRQAARHNAAMKALQAL 179  human
Q5M7M7       159 ---PMLKTFYVQLTVGNSEFYGEGKTRQAARHNAALKALHAL 197  tropical clawed frog
Q7ZW47       141 ---PVPKVFYVQLTVGNNEFIGEGRTRQAARHNAAMKALQAL 179  zebrafish
XP_014349083 213 ---PVPKIFYVQLTVGSSEFIGEGRTRQAARHNAAMKALQVL 251  coelacanth
XP_007885178 214 ---PAPKLFYVQLLVGNTEFIGEGRTRQAARHNAAMKALQAL 252  elephant shark
NP_001026112 213 ---PVPKIFYVQLTVGNSEFFGEGKTRQAARHNAAMKALQAL 251  chicken
ELT94341     233 --kYPPRVFYVSLKVGHREFIGEGSTRQAARHSAAEKALRVL 272  Capitella teleta
XP_006811959 215 ---PMARPCYVSLTVGNREFIGDGRTRQQARHNAALKALKVL 253  Saccoglossus kowalevskii
XP_023933375 264 ---KAQKVFYVSLKVGNREFMGEGNTRQAARHLAASKALKTL 302  Lingula anatina
EEN44004     214 ---PTPKTFYVSLTIGNREFIGEGRTRQQARHNAAAKALKVL 252  Florida lancelet
Q3L1C9       503 hypRMNRAFYVSLRVGHREFIGDGPTRQAARHNAAQKALRIL 544  California sea hare
KFM77620     240 ---PKVPTYYVSLKVGTRQFFGEGRTAQAARHAAAEEALSIL 278  Stegodyphus mimosarum
PNF27241     340 pggFQPSLFMVSLRVGTRDFLGEGPTAQAARHDAASKALHQL 381  Cryptotermes secundus

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