2VHF


Conserved Protein Domain Family
Bbox1_CYLD
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cd19816: Bbox1_CYLD 
B-box-type 1 zinc finger found in tumor suppressor cylindromatosis (CYLD) and similar proteins
CYLD, also termed ubiquitin carboxyl-terminal hydrolase CYLD, or deubiquitinating enzyme CYLD, or ubiquitin thioesterase CYLD, or ubiquitin-specific-processing protease CYLD, is a microtubule-associated deubiquitinase that specifically cleaves Lys-63-linked polyubiquitin chains. It plays a pivotal role in a wide range of cellular activities, including innate immunity, cell division, and ciliogenesis. CYLD antagonizes NF-kappaB and JNK signaling by disassembly of Lys63-linked ubiquitin chains synthesized in response to cytokine stimulation. Structural characterization reveals a small zinc-binding B-box inserted within the ubiquitin specific protease (USP) domain of CYLD. The B-box motif shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs) and is responsible for its intermolecular interaction and cytoplasmic localization. The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.
Links
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Statistics
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PSSM-Id: 380874
Aligned: 26 rows
Threshold Bit Score: 45.9255
Created: 13-Sep-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:2VHF; Homo sapiens CYLD binds two Zn2+ ions through the B-box motif within its USP domain.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #       #  #              #  #       #       #        
2VHF_A        203 PRQCRiCGgLAMYECRECYDdpdisagkikqFCKTCNTq---vHLHPkrlnHKYNPVSLP 259  human
XP_009860718  815 PRSCTvCGgLAEFECKQCSVersmq-ehissYCVQCAKr---cHQHPlrrqHNYQKIEVC 870  vase tunicate
XP_006811818  778 PRQCTiCShLAKYECRDCNVeksfvtdqitsYCGGCVEr---tHQHPkrekHNYKELKIM 834  Saccoglossus kowalevskii
OXA57263     1477 PRLCI-CGmVATYECLQCTHkssd---kalvYCDNCASlsdqiHFQLa---HDSSLVEII 1529 Folsomia candida
XP_018090694  388 SQVCCkCQePADYRCSQCFAdplttdgqicqYCHLCETq---iHKQLk--dHHPRRLDVQ 442  African clawed frog
XP_021949307  911 PKRCL-CEmAATFECAVCYKtyge---valaYCQTCQRmseqiHFHMg---HNPVLVPKL 963  Folsomia candida
PAA55907      682 ARACNiCGnFATIECHQCFLkhdsg--rdytYCEPCYKmf-adHRKGk--tHEPIKIKYP 736  Macrostomum lignano
XP_022647024  432 PRPCHvCAgLAQVECPDCYThvkai--erstFCDACYNr---tHLRMp--tHRGSAKRRL 484  honeybee mite
NP_001255045  955 VPACSkCQaCSEVYCPTCFLtrrvf-yseviFCRKCFHh---tHLLPeiedHKSRDLYPP 1010 Caenorhabditis elegans
KIO10611       48 PQNCIsCGtDGLYRCTDCLHqp--------mFCRECCRm---tHQRLl--fHRVQHWNGE 94   Pisolithus tinctorius Marx 270

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