Conserved Protein Domain Family
Bbox1_RNF207-like
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cd19814: Bbox1_RNF207-like 
B-box-type 1 zinc finger found in RING finger protein 207 (RNF207) and similar proteins
RNF207 is a cardiac-specific E3 ubiquitin-protein ligase that plays an important role in the regulation of cardiac repolarization. It regulates action potential duration, likely via effects on human ether-a-go-go-related gene (HERG) trafficking and localization, in a heat shock protein-dependent manner. RNF207 contains a RING finger, a B-box motif and Bbox C-terminal (BBC) domain, as well as a C-terminal non-homologous region (CNHR). The B-box motif shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.
Links
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Statistics
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PSSM-Id: 380872
Aligned: 23 rows
Threshold Bit Score: 56.2108
Created: 4-Sep-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens Midline-1 (2JUN) binds two Zn2+ ions through its B-box motif.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #              #  #    #  #    #        #          
Q6ZRF8         97 RCANCDLEcseqdveTTYFCNTCGQPLCARCRDeTHRARMFAR-HDIVALGQRSR 150  human
Q60MF5         72 QCANCEQIt-----lPMFYCETCQQSLCLACRNvTHQARMFSS-HKIISSEERSK 120  Caenorhabditis briggsae
XP_004347468  318 TCANCEQHq------ADFFCNTCEAPLCQVCRQtTHSARLFQS-HNVVGLSDVAT 365  Capsaspora owczarzaki ATCC 30864
XP_009492763  511 VCANCNGPs------VDWYCKTCASFICDPCYQdVHQARMYRK-HEVVRAHFSTT 558  Fonticula alba
EKC33068       12 RCTLCKSSi------APMHCDICHVNLCKDCVE-THISDVTKD-HKVVPLKHRGF 58   Pacific oyster
XP_011418717   14 ECDLCETP-------VSFYCRRCGVNLCDSCLP-IHMRVKSKNgHDVVDYVSKDD 60   Pacific oyster
XP_011676460  104 LCTVCDDVdq---glATFYCQHCAEFLCDSCLE-QHKRFKKYVvHELVSARDIAS 154  purple sea urchin
XP_011683436   89 HCSVCEEGee---spAAAYCQTCNDHLCEDCLD-VHRKWKKNAkHEVVNIDDIKT 139  purple sea urchin
XP_022343742   14 PCTLCDGI-------AEYHCDTCGDDLCQVCRK-GHLRSNASKlHQVVSYSDKYT 60   eastern oyster
XP_022303243   15 RCSLCESG-------AYYHCFKCRTILCDDCTS-AHLSDKSKN-HEIVSYTSQKR 60   eastern oyster

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