Conserved Protein Domain Family
Bbox2_TRIM44
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cd19784: Bbox2_TRIM44 
B-box-type 2 zinc finger found in tripartite motif-containing protein 44 (TRIM44) and similar proteins
TRIM44, also termed protein DIPB, functions as a critical regulator in tumor metastasis and progression. TRIM44 belongs to an unclassified TRIM (tripartite motif) family of proteins that do not have RING fingers and thus lack the characteristic tripartite (RING (R), B-box, and coiled coil (CC)) RBCC motif. It contains a Bbox2 domain. The type 2 B-box (Bbox2) zinc finger is characterized by a CHC3H2 zinc-binding consensus motif.
Links
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Statistics
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PSSM-Id: 380842
Aligned: 6 rows
Threshold Bit Score: 69.8015
Created: 5-Sep-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C H C [HD] C C H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens Midline-1 (2JUN) binds two Zn2+ ions through its B-box motif.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #       #  #    #  #     #  #     
Q96DX7       177 RKCPdHGLdLSTYCQEDRQLICVLCPVigaHQgHQLSTL 215 human
XP_018115760  85 KRCPiHQQeLTLYCREDQKIICVLCAVmgdHRqHQLITL 123 African clawed frog
XP_007903032 116 KKCPeHNQeITLYCKDDEKIICVLCAVg-pHRqHELITL 153 elephant shark
EMP40066      77 KKCEeHGQeLSLYCKEHEKIICVLCAVtgtHRqHQLITL 115 Green sea turtle
AAH95875      91 LKCRdHGQeGALYCKHDQRIICVLCAVqgeHRgHQIITL 129 zebrafish
XP_006002080  96 KKCAeHGQeLNLYCKPDEKIICVLCAIagaHStHELITL 134 coelacanth

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