Conserved Protein Domain Family
Bbox2_TRIM40_C-V
?
cd19781: Bbox2_TRIM40_C-V 
B-box-type 2 zinc finger found in tripartite motif-containing protein 40 (TRIM40) and similar proteins
TRIM40, also termed probable E3 NEDD8-protein ligase, or RING finger protein 35, may function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. It promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting NF-kappaB nuclear translocation and activity. TRIM40 belongs to the C-V subclass of TRIM (tripartite motif) family of proteins that are defined by an N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a RING finger, Bbox2, and a coiled coil region. The type 2 B-box (Bbox2) zinc finger is characterized by a CHC3H2 zinc-binding consensus motif.
Links
?
Statistics
?
PSSM-Id: 380839
Aligned: 8 rows
Threshold Bit Score: 65.5187
Created: 11-Sep-2018
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C H C [ED] C C H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens Midline-1 (2JUN) binds two Zn2+ ions through its B-box motif.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #       #  #    #  #     #   #        
Q6P9F5        67 TGYICPNHQKRVCRFCEESRLLLCVECLvsPEHMS-HHELTIENA 110 human
XP_007483528  67 AGYYCEVHQKKVGWFCEEKQVFLCPDCYksPEHQD-HYDQPIDKA 110 gray short-tailed opossum
OMJ96186     141 RRVLCTEHFEELEWFCTEEKILLCSICL--PKHQD-HHVLNKAQA 182 Stentor coeruleus
XP_007532389  90 AGYICQRHQKKVHYFCEVNKLLLCEECKksPKHKS-HEDLATEKA 133 western European hedgehog
XP_012380004  63 AGYVCQRHEKKVSWFCEDSHLLLCEECLasSEHRPpHLLAIEDAI 107 nine-banded armadillo
NP_001076539  88 SVGFCSLHKEPLDFFCTQDQVMICGKCRstTVHKN-HHIRSAEDA 131 zebrafish
XP_012863763  16 KNNLCMLHEEEVQGFCVVDEVPICEVCLlsLEHQS-HVVITLGDT 59  small Madagascar hedgehog
XP_006834577  88 KNSLCKIHENKAEHFCVVDQVPLCDICFqsPEHQF-HVEFTIEET 131 Cape golden mole

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap