3WVF,3WO7,3WO6


Conserved Protein Domain Family
5TM_YidC_Oxa1_Alb3

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cd19751: 5TM_YidC_Oxa1_Alb3 
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases
The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Statistics
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PSSM-Id: 410992
Aligned: 4 rows
Threshold Bit Score: 239.763
Created: 17-Jul-2016
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3WVF_A 355 GFSIIIITFIVRgIMYPLTKAQYTSMAKMRMLQPkiqAMRERLGddk-------qrISQEMMALYKAEKVnplgGCFPLL 427 Escherichia coli UTI89
3WO7_A  37 GLSIIIVTILIRlALLPLTLKQQKSMRAMQVIRPemeAIQKKYKekaskdpkvqqeMQKELLGLYQKHGVnpmaGCLPLF 116 Bacillus halodurans C...
3WO6_A  37 GLSIIIVTILIRlALLPLTLKQQKSMRAMQVIRPemeAIQKKYKekaskdpkvqqeMQKELLGLYQKHGVnpmaGCLPLF 116 Bacillus halodurans C...
Q42191 153 WASIVVATILIRsSTVPLLIKQMKDTTKLALMRPrleSIREEMQnkgmds-vtmaeGQKKMKNLFKEYGVtpftPMKGMF 231 thale cress
3WVF_A 428 IQMPIFLALYYMLMgs----veLRQAPFAlwiHDLSAQdpyyiLPILMGVTMFFIQKMspttvt---------------- 487 Escherichia coli UTI89
3WO7_A 117 IQLPILMAFYFAIMrt----eeIRYHTFLw--FDLGQPdy--iLPFVAGITTYFQFKMtmshqqqmqktnpsdsdnpman 188 Bacillus halodurans C...
3WO6_A 117 IQLPILMAFYFAIMrt----eeIRYHTFLw--FDLGQPdy--iLPFVAGITTYFQFKMtmshqqqmqktnpsdsdnpman 188 Bacillus halodurans C...
Q42191 232 IQGPLFICFFLAIRnmaekvpsFQTGGALw-fTDLTTPdslyiLPVITGLTFLITVECnaqegmegn------------- 297 thale cress
3WVF_A 488 --dpmqqkIMTFMPVIFTVFFLWfpsgLVLYYIVSNLVTIIQQQLIYR 533 Escherichia coli UTI89
3WO7_A 189 mmqmqmkvMLYVMPVMIIIAGLSlpsaLSLYWVIGNIFMIIQTYFIVV 236 Bacillus halodurans C-125
3WO6_A 189 mmqmqmkvMLYVMPVMIIIAGLSlpsaLSLYWVIGNIFMIIQTYFIVV 236 Bacillus halodurans C-125
Q42191 298 pmagtvktVCRVFALLTVPMTMSfpqaIFCYWITSNLFSLMYGLVIKR 345 thale cress
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