Conserved Protein Domain Family
bHLH-PAS_dSIM_like
?
cd19740: bHLH-PAS_dSIM_like 
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Drosophila melanogaster protein single-minded (SIM) and similar proteins
SIM is a nuclear bHLH-PAS transcription factor that functions as a master developmental regulator controlling midline development of the ventral nerve cord in Drosophila.
Links
?
Statistics
?
PSSM-Id: 381583
Aligned: 4 rows
Threshold Bit Score: 139.049
Created: 2-Jul-2018
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus NPAS3 (5SY7)-ARNT complex binds HRE DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1      # ###   # ##   #                    ##                       
P05709     25 MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGE 86  fruit fly
EFX87839    1 MKEKSKNAARSRREKENAEFMELAKMLPLPSAITSQLDKASVIRLTTSYLKMRQVFPDGLGD 62  common water flea
BAE87099    1 MKEKSKNAARSRREKENAEFLELAKLLPLPPAITSQLDKASIIRLTTSYLRMREVFPKGLGD 62  common house spider
ELU00285    1 MKEKSKNAARTRREKENSEFFDLAKMLPLPAAITSQLDKASIIRLTTSYLKMRTVFPDGLGD 62  Capitella teleta

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap