Conserved Protein Domain Family
bHLH-PAS_PASD1
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cd19736: bHLH-PAS_PASD1 
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in circadian clock protein PASD1
PASD1, also termed PAS domain-containing protein 1, is evolutionarily related to Circadian locomotor output cycles protein kaput (CLOCK)and functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Mammalian PASD1 doesn't harbor the bHLH-PAS domain and is not included in this family.
Links
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Statistics
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PSSM-Id: 381579
Aligned: 6 rows
Threshold Bit Score: 100.165
Created: 6-Jul-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Homo sapiens CLOCK (4H10)-BMAL1 basic helix-loop-helix domains binds E-box DNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #  ##  ## ##   #                   ##                       
XP_007664082   1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELCTMLQGHGHplKMDKSTILQRTIDFLQKQKEITAQSEA 70  platypus
ETE56431       1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELCTMLQGHGHplKMDKSTILQRTIDFLQKQKERILSLER 70  king cobra
OCT67565       1 MDEDEKERTKRASRNKSEKKRRERFNVLIKELCTMLQGHGQplKMDKSRILQKTIDFLQKQKEITAQTEA 70  African clawed frog
XP_007891228  12 MDEDDKDRAKRASRNKSEKKRRDQFNVLIKELSTMLQGSTR--KMDKSTVLQRTIDFLQKQKEISAQTEA 79  elephant shark
NP_840084     34 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELCTMLQGQGHprKMDKSTILQRTIDFLQKQKEITAQTES 103 zebrafish
XP_014341507   1 MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELCTMLQGQGHprKMDKSTILQRTINFLQKQKEITAQTEA 70  coelacanth

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