Conserved Protein Domain Family
bHLH_TS_dimmed_like

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cd19712: bHLH_TS_dimmed_like 
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein dimmed and similar proteins
Dimmed, also termed DIMM, is a bHLH transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate in Drosophila.
Statistics
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PSSM-Id: 381555
Aligned: 9 rows
Threshold Bit Score: 110.27
Created: 3-Aug-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #   # ### #    #                 ####                      
B6VQA1       157 RRLESNERERMRMHSLNDAFQSLREVIPHVeMERRLSKIETLTLAKNYIINLTHIILSKR 216 fruit fly
OQR73778     151 RRLESNERERMRMHSLNDAFQALREVIPHVaMERKLSKIETLTLAKNYIMALTNVICDIR 210 Tropilaelaps mercedesae
XP_013410423 149 RRLESNERERMRMHSLNDAFEGLRQVIPHVkLDRKLSKIETLTLAKNYIKALTNVICGLR 208 Lingula anatina
ELT92402     144 RRLESNERERMRMHSLNDAFQGLREVIPHVkIGRKLSKIETLTLAKNYIKALTNVVCEMR 203 Capitella teleta
OWF53644      89 RRIESNERERMRMHSLNDAFQDLREVIPHVeLERKLSKIETLTLAKNYIKALTNVICEFR 148 Yesso scallop
EFX66957     109 RRLESNERERLRMHGLNAAFEELRTVIPHIqVERKLSKIETLTLAKNYIMALTNVICDIR 168 common water flea
PIK61090     104 RRLESNERERMRMHTLNDAFQGLRNTIPHVhAQRKLSKIETLTLAKNYILSLTDVVVKLK 163 Japanese sea cucumber
XP_019641967 109 RRLESNERERQRMHSINDAFQGLRDVIPHVnADRKLSKIETLTLAQNYIVALTGIVCKLQ 168 Belcher's lancelet
XP_006822740  89 RRLESNERERMRMHSLNDAFQNLRDVIPHVnCERKLSKIETLTLAKNYISALTGVITEMK 148 Saccoglossus kowalevskii

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